Hey Jon

[Klaus]

Wow, that sucks. I'm sorry to hear that.

Would it make a difference if you'd increase the volume of a dose? Like, take three shots at once?

[Klaus]

Maybe you find this interesting? Maybe you've already seen it.

https://www.sciencemag.org/news/2021/04/covid-19-vaccines-may-protect-many-not-all-people-suppressed-immune-systems?utm_campaign=NewsfromScience&utm_source=Contractor&utm_medium=Twitter

[brenda]

Jon, it would be worth getting the additional shots. My completely unprofessional advice is that it shouldn't hurt you, and it might be the only way to build immunity. I wish you the best results as you go forward, and it's great you have excellent professional support for your options.

[jon-nyc]

@klaus said in Hey Jon:

Wow, that sucks. I'm sorry to hear that.

Would it make a difference if you'd increase the volume of a dose? Like, take three shots at once?

Well the response is dose dependent so something like that. The problem is no institution will do that today except as part of a registered clinical trial.

I’ll likely do it my own sneaky way at some point. Keep in mind there’s still hope for a B-cell and T-cell response.

[jon-nyc]

@klaus hadn’t seen that science piece but it reports on the same Johns Hopkins study

[jon-nyc]

That piece in science says they saw some improvement after dose 2 and that their data will be out shortly.

[Axtremus]

Thanks for your excellent explanation, @jon-nyc .
Didn’t realize that the vaccine efficacy data look so grim for transplant survivors on immunosuppressants. Here’s hoping for robust T-cell and B-cell responses for this population.

[jon-nyc]

6 weeks after shot 2. Sigh.

[Mik]

Damn. Damn, damn, damn.

So N95 for the foreseeable future?

[jon-nyc]

By the way, the UK announced they’ll be offering a 3rd shot to over-50s in the fall. That makes me feel more comfortable going “off-label” and securing a 3rd and possibly a 4th shot.

[jon-nyc]

@mik Just ordered some more.

[Mik]

Yeah, I would not hesitate to get another shot or two. Especially since it is getting easier to do so.

[jon-nyc]

Dose 3 scheduled at 10:45. A rite aid in the Bronx.

[Axtremus]

@jon-nyc, no word on T-cell and B-cell memories yet?
Sorry it looks like this makes you more dependent on others getting vaccinated, on herd immunity.

[jon-nyc]

@axtremus Give up I shall not.

Have not yet done the check for B and T cell response.

[jon-nyc]

I’m in the waiting area now. Much more chill than in March at Javits. Lol

[Doctor Phibes]

Jon, are you getting the same Pfizer shot, or have you considered mixing them up? I heard a discussion on the radio the other day that there's a theory that using different vaccines could increase their effectiveness. For obvious reasons, it's not something that was tested in development.

[jon-nyc]

Thought about Moderna and discussed it with a few docs. They thought a Pfizer booster would be better.

[Doctor Phibes]

The theory is that two different vaccines is a bit like showing your immune systems two different profiles of the same face. It made sense to my totally uneducated brain, but those damn doctors probably know better.

[jon-nyc]

Well, they just thought that, since the Pfizer response is dose dependent, it would be the most straightforward way.