Hey Jon

[jon-nyc]

That piece in science says they saw some improvement after dose 2 and that their data will be out shortly.

[Axtremus]

Thanks for your excellent explanation, @jon-nyc .
Didn’t realize that the vaccine efficacy data look so grim for transplant survivors on immunosuppressants. Here’s hoping for robust T-cell and B-cell responses for this population.

[jon-nyc]

6 weeks after shot 2. Sigh.

[Mik]

Damn. Damn, damn, damn.

So N95 for the foreseeable future?

[jon-nyc]

By the way, the UK announced they’ll be offering a 3rd shot to over-50s in the fall. That makes me feel more comfortable going “off-label” and securing a 3rd and possibly a 4th shot.

[jon-nyc]

@mik Just ordered some more.

[Mik]

Yeah, I would not hesitate to get another shot or two. Especially since it is getting easier to do so.

[jon-nyc]

Dose 3 scheduled at 10:45. A rite aid in the Bronx.

[Axtremus]

@jon-nyc, no word on T-cell and B-cell memories yet?
Sorry it looks like this makes you more dependent on others getting vaccinated, on herd immunity.

[jon-nyc]

@axtremus Give up I shall not.

Have not yet done the check for B and T cell response.

[jon-nyc]

I’m in the waiting area now. Much more chill than in March at Javits. Lol

[Doctor Phibes]

Jon, are you getting the same Pfizer shot, or have you considered mixing them up? I heard a discussion on the radio the other day that there's a theory that using different vaccines could increase their effectiveness. For obvious reasons, it's not something that was tested in development.

[jon-nyc]

Thought about Moderna and discussed it with a few docs. They thought a Pfizer booster would be better.

[Doctor Phibes]

The theory is that two different vaccines is a bit like showing your immune systems two different profiles of the same face. It made sense to my totally uneducated brain, but those damn doctors probably know better.

[jon-nyc]

Well, they just thought that, since the Pfizer response is dose dependent, it would be the most straightforward way.

[taiwan_girl]

@jon-nyc sending positive thoughts (and antibodies) to you!

[Jolly]

@jon-nyc said in Hey Jon:

6 weeks after shot 2. Sigh.

Decent box, decent test.

Hope the next shot works better for you...

[LuFins Dad]

The good news is that you can sell the extra Vaccination Card on the black market for good $$!

Seriously, thoughts and prayers are with you!

[jon-nyc]

Hopkins' summary of second shot data is out in Jama today.

Summary: the percentage of people showing an antibody response jumped from ~15% to ~54%. Though the response levels were quite a bit below immunocompetent people.

All in all decent news, and gives me hope for my 3rd shot.

https://jamanetwork.com/journals/jama/fullarticle/2779852

[Axtremus]

@jon-nyc , just curious if there's been any more optimistic development with regards to your antibody response or T-cell memory or whatever. How has it been since the 3rd shot?