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A place to talk about whatever you want

37.9k Topics 342.8k Posts
  • Nah, they wouldn't do that. Would they?

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    jon-nycJ
    $100 says Jesse Jack uploaded that cover so this outrage would go viral and goose his book. And yes, Jolly, he would do that.
  • He has his own bowl now.

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    LWL
    @Aqua-Letifer one was a big white one with red eyes, one was brown like a typical wild rabbit, and one was like your dude with lop ears. Beyond their colors and names (Alex, BunBun, and Raoul) I have no clue. They were all very sweet.
  • Somebody hand her a broomstick.

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  • Darn good thing she wasn't a praying grandmother!

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  • The Secret to Cooking an Omelette In a Stainless Steel Pan

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    George KG
    I've been letting my stainless steel set languish for years, having used nothing than my Anolon X non-stick and my cast iron. Thought I'd try an omelet today. I used this guys technique... Link to video I pre-heated on low/medium heat. As he suggests - turn it down to low. Came out perfect. No sticking, and it slid right out of the pan.
  • Anesthesia vs. CO2

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    George KG
    The interplay of CO2, inhalation anesthetics, cerebral autoregulation of blood flow has been a delicate dance that I've been aware of for (checks calendar) 45 years. Gelb, A. W., & Bayona, N. A. (2005). "Anesthesia and cerebral blood flow." Current Opinion in Anesthesiology, 18(6), 537-542. Laffey, J. G., & Kavanagh, B. P. (2002). "Hypocapnia." The New England Journal of Medicine, 347(1), 43-53. Eintrei, C., & Varnauskas, E. (1993). "Effects of isoflurane, halothane, and enflurane on cerebral blood flow and metabolism." Anesthesiology, 78(5), 976-982. In most instances, you want to maintain normocapnia (normal CO2) levels during anesthesia. In some cases, where there is brain swelling, hypocapnia is indicated to reduce cerebral blood flow and therefore reduce swelling. The effect of anesthetic gasses on CBF autoregulation has been studied for a long time. What's new is that there are now intravenous drugs that can minimize that change. Bottom line - these are physiologically-interesting studies, but have very little practical effect in the majority of cases. From the original article: Editor’s Perspective What We Already Know about This Topic Cerebrospinal fluid flow via the perivascular glymphatic clearance pathway is important to maintain central nervous system homeostasis General anesthetics and carbon dioxide have major influence on cerebral vasomotor tone and, therefore, can influence glymphatic cerebrospinal fluid dynamics The combined influence of general anesthetics and varying carbon dioxide levels on cerebrospinal fluid dynamics is unexplored What This Article Tells Us That Is New In ventilated rats under physiologic carbon dioxide levels, ketamine–dexmedetomidine anesthesia led to cerebral vasoconstriction and concomitant increases in cerebrospinal fluid space size, whereas isoflurane anesthesia had opposite effects In hypercapnic conditions, ketamine–dexmedetomidine anesthesia preserved the total intracranial cerebrospinal fluid volume, and hyperventilation-induced hypocapnia did not change cerebrospinal fluid volume under isoflurane anesthesia These observations suggest that general anesthetics are potent modulators of cerebrospinal fluid space and can overcome the influence of carbon dioxide on cerebrospinal fluid dynamics I italicized the potentially important one. Now, having said that, I've hyperventilated patients with increased intracranial pressure at the request of the surgeon. I have no idea what the blood flow to the brain was, but I can attest that both he and I saw the brain shrink. So there's that. Other things to note: The CO2 in this rat study was 80 mmHg. That's more than twice normal CO2 in a human, and a rat. If I had a patient with a CO2 that high, there would be other signs that things are not going well. Similarly a CO2 of 20 is pretty profound hyperventilation. Most humans would have to breathe into a paper bag to avoid passing out at that level. Interesting, but I wonder how practically important it is.
  • Buy Guns

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  • A New Cover

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  • Star Trek original trailer

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    CopperC
    In color!
  • The Kremlin Caucus

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    taiwan_girlT
    I can understand them not knowing and not looking too closely at who was the ultimate payer. Doesn't make them look any better, but I could see most people not really checking.
  • Indiana Jones: Time to let it die?

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    George KG
    @LuFins-Dad said in Indiana Jones: Time to let it die?: @George-K said in Time to let it die?: I'd never heard of Kennedy until looking into this story. ETA: Looking at her Wikipedia page, it's an impressive run. She killed Star Wars. [image: 1725885070142-screenshot-2024-09-09-at-7.30.08-am.png]
  • OMG

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    jon-nycJ
    Not sure what happened. It was one of those ‘guess the diagnosos’ accounts that showed surgeons taking out a 3’ or so parasite from a gut. As it was fully removed it started wiggling. It was probably 2” in diameter.
  • Cornerstone Chapel probably just lost it’s 501C3 status…

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    JollyJ
    Don't care for the Saturday morning super casual stuff (at least tuck your shirt in), but I agree with much of his message. I've heard the verses in Ezekiel preached several times over the years, even a little bit similar to this. I do appreciate the weaving of Scripture in to support his preaching points, although I would like more exposition. But I understand why he's doing what he's doing. As for the gist if the sermon, I find many points to agree with. He makes a better argument than I about voting for flawed candidates and I hope people took that message to heart. It's the only practical way for a Christian to address so many things in politics. There was only one perfect man and they nailed Him to a cross. He does overstate the number if Evangelicals. The number referenced is self-described, by the widest criteria. By theological definition, I think that number is probably around 30M. But that's quibble. I thought he preached a good sermon. Maybe Jon ought to give it a listen.
  • Unusual weather in Central Europe

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    jon-nycJ
    Not really except for dinner tonight. But I’ve been here several times, including with the boy.
  • Pats win!

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    LuFins DadL
    @Jolly said in Pats win!: Right now, Washington trails Tampa in the third. But guys, I'm tellin' ya, if Daniels can stay in one piece, he's going to make them a decent QB. Plenty of decent QBs out of the league by year 3.
  • Bullseye: Northwestern

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    LuFins DadL
    Here’s my proposal the first two years of a PELL Grant can ONLY be used at a Community College or Trade School. Any student applying for a loan must pass an exam where they calculate out the monthly interest of the loan and show the the total amount paid over 10 years.
  • I guess he knows what he is talking about...

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  • Legal Exposure?

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  • Bigger IS Better

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    MikM
    I always always do my research first and know who I want to see. I’ll usually take my PCPs recommendation because he’s very well connected in my system, but I still research them first. Physicians are not interchangeable widgets, which is why I despise the hospitalist system.
  • Meanwhile, in Louisiana

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