Pseudocholinesterase deficiency (aka butyrylcholinestesterase) is something that every anesthesiologist is familiar with. Pseudocholinesterase is involved with the metabolism of succinylcholine, a paralytic drug. Mild deficiencies cause a drug that should last 5-10 minutes to last an hour or so. Severe deficiencies can cause you to be paralyzed for hours and hours.
I've seen a couple, but only one was undiagnosed. Well, I should say it was diagnosed by me, LOL.
It's an autosomal dominant trait, and it's no big deal, if you know about it beforehand.
There is no treatment, afaik.
https://en.wikipedia.org/wiki/Pseudocholinesterase_deficiency