If Remdesivir Really Fails...
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wrote on 26 Apr 2020, 12:43 last edited by
Convalescent plasma?
Hyperimmune globulin?
One thing that I find encouraging is we've never had so many scientists/companies etc working on one very specific condition. There are probably a lot of candidate molecules being studies hard right now.
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Convalescent plasma?
Hyperimmune globulin?
One thing that I find encouraging is we've never had so many scientists/companies etc working on one very specific condition. There are probably a lot of candidate molecules being studies hard right now.
wrote on 26 Apr 2020, 12:47 last edited by@jon-nyc said in If Remdesivir Really Fails...:
Convalescent plasma?
I've read that the immunity it affords is short-term, though it might be helpful as a therapy.
One thing that I find encouraging is we've never had so many scientists/companies etc working on one very specific condition.
Indeed. It's amazing to see this.
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wrote on 26 Apr 2020, 12:55 last edited by
Is this an unintended "moon shot"?
And yes, this is very grim news.
I guess the new "normal" will not look much like the old "normal".
One of my best friends is heading out to golf with 3 people he doesn't even know later today.
I would golf solo, but none of the courses are permitting that. They are bundling people into foursomes. Pre-pay online only.
All the tee times are booked through mid-week. And all are full foursomes.
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wrote on 26 Apr 2020, 13:18 last edited by Copper
I've played the last 5 days, Sunday is my day off.
Weekdays I've played alone or with 1 other guy. Yesterday was with the 20 man Saturday group.
Every round everyone is in a cart by himself or walking. Guys try to maintain 6+ feet. There are devices in the holes that stop the ball from going all the way in so it can be removed without touching anything, the pins remain in the hole. All the bunker rakes have been removed.
The clubhouse and restaurant are closed except for take-out. You can buy a beer and drink it outside, sitting at a table were, for the most part, 6+ feet is maintained.
For the first time yesterday I saw a guy wearing a mask. The parking lot was crowded yesterday.
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@jon-nyc said in If Remdesivir Really Fails...:
Convalescent plasma?
I've read that the immunity it affords is short-term, though it might be helpful as a therapy.
One thing that I find encouraging is we've never had so many scientists/companies etc working on one very specific condition.
Indeed. It's amazing to see this.
wrote on 26 Apr 2020, 13:23 last edited by@George-K said in If Remdesivir Really Fails...:
@jon-nyc said in If Remdesivir Really Fails...:
One thing that I find encouraging is we've never had so many scientists/companies etc working on one very specific condition.
Indeed. It's amazing to see this.
Such a well defined problem which hasn't been extensively studied for years by the whole scientific community and with such a massive pot of glory for whomever cracks it, is a once in a lifetime opportunity.
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wrote on 26 Apr 2020, 13:28 last edited by Copper
Also a great opportunity to throw caution to the wind and make a giant leap.
The opportunity reminds me of Apollo. It has driven the economy for 50 years since.
Apollo had a lot of screwball ideas in the beginning, there will be some here.
Cigarettes might even make a comeback.
From the Apollo era:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444439/
@NIH said "
Abstract
A water-soluble nontumorigenic acidic fraction of tobacco smoke condensate of cigarettes has been found to have antiviral activity against encephalomyocarditis (EMC) virus infection in mice. -
Is this an unintended "moon shot"?
And yes, this is very grim news.
I guess the new "normal" will not look much like the old "normal".
One of my best friends is heading out to golf with 3 people he doesn't even know later today.
I would golf solo, but none of the courses are permitting that. They are bundling people into foursomes. Pre-pay online only.
All the tee times are booked through mid-week. And all are full foursomes.
wrote on 27 Apr 2020, 19:01 last edited by@mark said in If Remdesivir Really Fails...:
Is this an unintended "moon shot"?
And yes, this is very grim news.
I guess the new "normal" will not look much like the old "normal".
One of my best friends is heading out to golf with 3 people he doesn't even know later today.
I would golf solo, but none of the courses are permitting that. They are bundling people into foursomes. Pre-pay online only.
All the tee times are booked through mid-week. And all are full foursomes.
Maybe Barry has a spot for you?
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wrote on 28 Apr 2020, 03:09 last edited by
So it looks like he’s playing RTJ, a very private club...which coincidentally I had a tee time to play there this past Thursday (I won it in a charity auction) but the club canceled it on me. How dare they think Obama is more of a VIP than me!
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wrote on 28 Apr 2020, 21:55 last edited by
@jon-nyc said in If Remdesivir Really Fails...:
And a fine morning to you too, George.
Another thing to cheer you up:
Chinese scientists say the novel coronavirus will not be eradicated, adding to a growing consensus around the world that the pathogen will likely return in waves like the flu.
It’s unlikely the new virus will disappear the way its close cousin SARS did 17 years ago, as it infects some people without causing obvious symptoms like fever. This group of so-called asymptomatic carriers makes it hard to fully contain transmission as they can spread the virus undetected, a group of Chinese viral and medical researchers told reporters in Beijing at a briefing Monday.
With SARS, those infected became seriously ill. Once they were quarantined from others, the virus stopped spreading. In contrast, China is still finding dozens of asymptomatic cases of the coronavirus every day despite bringing its epidemic under control.
“This is very likely to be an epidemic that co-exists with humans for a long time, becomes seasonal and is sustained within human bodies,” said Jin Qi, director of the Institute of Pathogen Biology at China’s top medial research institute, the Chinese Academy of Medical Sciences.
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wrote on 28 Apr 2020, 22:01 last edited by
I watched the President's Cup matches at RTJ a couple times.
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@jon-nyc said in If Remdesivir Really Fails...:
And a fine morning to you too, George.
Another thing to cheer you up:
Chinese scientists say the novel coronavirus will not be eradicated, adding to a growing consensus around the world that the pathogen will likely return in waves like the flu.
It’s unlikely the new virus will disappear the way its close cousin SARS did 17 years ago, as it infects some people without causing obvious symptoms like fever. This group of so-called asymptomatic carriers makes it hard to fully contain transmission as they can spread the virus undetected, a group of Chinese viral and medical researchers told reporters in Beijing at a briefing Monday.
With SARS, those infected became seriously ill. Once they were quarantined from others, the virus stopped spreading. In contrast, China is still finding dozens of asymptomatic cases of the coronavirus every day despite bringing its epidemic under control.
“This is very likely to be an epidemic that co-exists with humans for a long time, becomes seasonal and is sustained within human bodies,” said Jin Qi, director of the Institute of Pathogen Biology at China’s top medial research institute, the Chinese Academy of Medical Sciences.
wrote on 29 Apr 2020, 00:15 last edited by@George-K I wasn’t supposed to drink today. There goes that plan.
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@George-K I wasn’t supposed to drink today. There goes that plan.
wrote on 29 Apr 2020, 00:34 last edited by@LuFins-Dad said in If Remdesivir Really Fails...:
@George-K I wasn’t supposed to drink today. There goes that plan.
I should retitle this the "Debbie Downer" thread.
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@jon-nyc said in If Remdesivir Really Fails...:
And a fine morning to you too, George.
Another thing to cheer you up:
Chinese scientists say the novel coronavirus will not be eradicated, adding to a growing consensus around the world that the pathogen will likely return in waves like the flu.
It’s unlikely the new virus will disappear the way its close cousin SARS did 17 years ago, as it infects some people without causing obvious symptoms like fever. This group of so-called asymptomatic carriers makes it hard to fully contain transmission as they can spread the virus undetected, a group of Chinese viral and medical researchers told reporters in Beijing at a briefing Monday.
With SARS, those infected became seriously ill. Once they were quarantined from others, the virus stopped spreading. In contrast, China is still finding dozens of asymptomatic cases of the coronavirus every day despite bringing its epidemic under control.
“This is very likely to be an epidemic that co-exists with humans for a long time, becomes seasonal and is sustained within human bodies,” said Jin Qi, director of the Institute of Pathogen Biology at China’s top medial research institute, the Chinese Academy of Medical Sciences.
wrote on 29 Apr 2020, 13:40 last edited by@George-K wait a minute! I thought they were saying that seasonal temp changes don’t have an effect on this thing?
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wrote on 29 Apr 2020, 13:55 last edited by
A government-run study of Gilead’s remdesivir, perhaps the most closely watched experimental drug to treat the novel coronavirus, showed that the medicine is effective against Covid-19, the disease caused by the virus.
Gilead made the announcement in a statement Wednesday, stating: “We understand that the trial has met its primary endpoint.” The company said that the National Institute of Allergy and Infectious Diseases, which is conducting the study, will provide data at an upcoming briefing.
The finding — although difficult to fully characterize without any data for the study — would represent the first treatment shown to improve outcomes in patients infected with the virus that put the global economy in a standstill and killed at least 218,000 people worldwide.
Gilead's Futures:
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wrote on 29 Apr 2020, 14:27 last edited by
It is so surprising that the most expensive drug of all the possible treatments is the only option passing clinical trials.
Shocking!
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wrote on 29 Apr 2020, 17:58 last edited by
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wrote on 29 Apr 2020, 18:00 last edited by
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@George-K I wasn’t supposed to drink today. There goes that plan.
wrote on 4 May 2020, 16:56 last edited by@LuFins-Dad said in If Remdesivir Really Fails...:
@George-K I wasn’t supposed to drink today. There goes that plan.
Here's another reason:
As President Trump presses for states to reopen their economies, his administration is privately projecting a steady rise in the number of cases and deaths from the coronavirus over the next several weeks, reaching about 3,000 daily deaths on June 1, according to an internal document obtained by The New York Times, nearly double from the current level of about 1,750.
The projections, based on modeling by the Centers for Disease Control and Prevention and pulled together in chart form by the Federal Emergency Management Agency, forecast about 200,000 new cases each day by the end of the month, up from about 25,000 cases now.The numbers underscore a sobering reality: While the United States has been hunkered down for the past seven weeks, not much has changed. And the reopening to the economy will make matters worse.
“There remains a large number of counties whose burden continues to grow,” the C.D.C. warned.
The projections confirm the primary fear of public health experts: that a reopening of the economy will put the nation right back where it was in mid-March, when cases were rising so rapidly in some parts of the country that patients were dying on gurneys in hospital hallways as the health care system grew overloaded.
“While mitigation didn’t fail, I think it’s fair to say that it didn’t work as well as we expected,” Scott Gottlieb, Mr. Trump’s former commissioner of food and drugs, said Sunday on the CBS program Face the Nation. “We expected that we would start seeing more significant declines in new cases and deaths around the nation at this point. And we’re just not seeing that.”
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@LuFins-Dad said in If Remdesivir Really Fails...:
@George-K I wasn’t supposed to drink today. There goes that plan.
Here's another reason:
As President Trump presses for states to reopen their economies, his administration is privately projecting a steady rise in the number of cases and deaths from the coronavirus over the next several weeks, reaching about 3,000 daily deaths on June 1, according to an internal document obtained by The New York Times, nearly double from the current level of about 1,750.
The projections, based on modeling by the Centers for Disease Control and Prevention and pulled together in chart form by the Federal Emergency Management Agency, forecast about 200,000 new cases each day by the end of the month, up from about 25,000 cases now.The numbers underscore a sobering reality: While the United States has been hunkered down for the past seven weeks, not much has changed. And the reopening to the economy will make matters worse.
“There remains a large number of counties whose burden continues to grow,” the C.D.C. warned.
The projections confirm the primary fear of public health experts: that a reopening of the economy will put the nation right back where it was in mid-March, when cases were rising so rapidly in some parts of the country that patients were dying on gurneys in hospital hallways as the health care system grew overloaded.
“While mitigation didn’t fail, I think it’s fair to say that it didn’t work as well as we expected,” Scott Gottlieb, Mr. Trump’s former commissioner of food and drugs, said Sunday on the CBS program Face the Nation. “We expected that we would start seeing more significant declines in new cases and deaths around the nation at this point. And we’re just not seeing that.”
wrote on 4 May 2020, 18:26 last edited by@George-K said in If Remdesivir Really Fails...:
“While mitigation didn’t fail, I think it’s fair to say that it didn’t work as well as we expected,” Scott Gottlieb, Mr. Trump’s former commissioner of food and drugs, said Sunday on the CBS program Face the Nation. “We expected that we would start seeing more significant declines in new cases and deaths around the nation at this point. And we’re just not seeing that.”
R never dropped below one. At least reliably and sustainably.
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wrote on 4 May 2020, 19:17 last edited by
Dewy and I don't agree on much anymore, but he posted this that I have shared freely.
