AstraZeneca’s vaccine for COVID-19

[Klaus]

Could anyone explain "This is the only western vaccine in such late stage without a stabilized Spike in the pre-fusion conformation." to me?

[Loki]

So less is more? And they thought to do the trial that way. Would be good to understand why.

[jon-nyc]

Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.

What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.

[bachophile]

@Klaus said in AstraZeneca’s vaccine for COVID-19:

Could anyone explain "This is the only western vaccine in such late stage without a stabilized Spike in the pre-fusion conformation." to me?

https://www.pnas.org/content/114/35/E7348

U figure it out

[Mik]

I take my vaccines cold. REAL cold.

[jon-nyc]

I take my vaccines like I take my women.

Extra cold and double dosed.

[jon-nyc]

@jon-nyc said in AstraZeneca’s vaccine for COVID-19:

What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise

I’m not the only one curious about this.

[Jolly]

At this point, 538 would not be my go-to for statistical anything...

[jon-nyc]

@jon-nyc said in AstraZeneca’s vaccine for COVID-19:

Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.

What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.

Wait, this wasn’t a ‘multiple ascending dose’ P2. It was p3 and the light dosing was an accident. Fairly low n of 3k. They’re going to have some explaining to do.

[jon-nyc]

Oh, and the reduced dosage set had a younger age profile.