AstraZeneca’s vaccine for COVID-19
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https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html
Claims 90% efficacy with half-dose than full-dose a month later, but only 60% if done with two full doses a month apart. No need for subzero storage, regular pharmacy refrigerators will be fine.
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Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.
What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.
The whole reason we call them illegal aliens is because they’re subject to our laws.
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Could anyone explain "This is the only western vaccine in such late stage without a stabilized Spike in the pre-fusion conformation." to me?
@Klaus said in AstraZeneca’s vaccine for COVID-19:
Could anyone explain "This is the only western vaccine in such late stage without a stabilized Spike in the pre-fusion conformation." to me?
https://www.pnas.org/content/114/35/E7348
U figure it out
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Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.
What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.
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Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.
What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.
@jon-nyc said in AstraZeneca’s vaccine for COVID-19:
Phase 2 trials often are ‘multiple ascending dose’ since they’re trying to balance safety and efficacy, which are presumed to be a trade off, and neither of which are known with much confidence going in.
What gets me is the lighter dose being more effective. Want to know their n and that it wasn’t just noise.
Wait, this wasn’t a ‘multiple ascending dose’ P2. It was p3 and the light dosing was an accident. Fairly low n of 3k. They’re going to have some explaining to do.
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