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The New Coffee Room

  1. TNCR
  2. General Discussion
  3. The bradykinin hypothesis

The bradykinin hypothesis

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  • jon-nycJ Offline
    jon-nycJ Offline
    jon-nyc
    wrote on last edited by
    #7

    Except will.

    "You never know what worse luck your bad luck has saved you from."
    -Cormac McCarthy

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    • jon-nycJ Offline
      jon-nycJ Offline
      jon-nyc
      wrote on last edited by
      #8

      In case anybody's curious.

      Screen Shot 2020-09-03 at 10.52.43 AM.png

      "You never know what worse luck your bad luck has saved you from."
      -Cormac McCarthy

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      • George KG Offline
        George KG Offline
        George K
        wrote on last edited by
        #9

        Link to video

        I've always pronounced it bray-dee-keye-nin. Every vowel is long other than the last "i".

        "Now look here, you Baltic gas passer... " - Mik, 6/14/08

        The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

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        • jon-nycJ Offline
          jon-nycJ Offline
          jon-nyc
          wrote on last edited by
          #10

          THat's what I assumed when I read it. But I googled it out of curiosity.

          "You never know what worse luck your bad luck has saved you from."
          -Cormac McCarthy

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          • George KG George K

            @brenda for months I've been saying that the SARS-CoV-2 infection is NOT a respiratory illness. It's a generalized vascular illness, with the lungs being one of the targeted organs.

            brendaB Offline
            brendaB Offline
            brenda
            wrote on last edited by
            #11

            @George-K said in The bradykinin hypothesis:

            @brenda for months I've been saying that the SARS-CoV-2 infection is NOT a respiratory illness. It's a generalized vascular illness, with the lungs being one of the targeted organs.

            You're smarter than the super computer! At least you're faster at figuring it out.

            How long until this changes the treatments for COVID-19?

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            • L Offline
              L Offline
              Loki
              wrote on last edited by
              #12

              Sounds scary as hell, yet so many people are asymptomatic and it kills very few young and healthy people. Doesn’t explain why that is so.

              Aqua LetiferA 1 Reply Last reply
              • RainmanR Offline
                RainmanR Offline
                Rainman
                wrote on last edited by
                #13

                I'd want the results double-checked by Mark's computer, just to be sure.

                markM 1 Reply Last reply
                • RainmanR Rainman

                  I'd want the results double-checked by Mark's computer, just to be sure.

                  markM Offline
                  markM Offline
                  mark
                  wrote on last edited by
                  #14

                  @Rainman said in The bradykinin hypothesis:

                  I'd want the results double-checked by Mark's computer, just to be sure.

                  lol, I better "up the spec" to the 64 core Threadripper and 256 Gigs of Ram. What's an extra $4.5k anyway?

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                  • L Loki

                    Sounds scary as hell, yet so many people are asymptomatic and it kills very few young and healthy people. Doesn’t explain why that is so.

                    Aqua LetiferA Offline
                    Aqua LetiferA Offline
                    Aqua Letifer
                    wrote on last edited by
                    #15

                    @Loki said in The bradykinin hypothesis:

                    Sounds scary as hell, yet so many people are asymptomatic and it kills very few young and healthy people. Doesn’t explain why that is so.

                    Yes it does. If the virus fails to incite the storm, prognosis is much, much better. That's why Vitamin D is helpful.

                    Please love yourself.

                    1 Reply Last reply
                    • jon-nycJ Offline
                      jon-nycJ Offline
                      jon-nyc
                      wrote on last edited by jon-nyc
                      #16

                      A most curious etymology.

                      From la wik:

                      Bradykinin was discovered in 1948 by three Brazilian physiologists and pharmacologists working at the Biochemistry and Pharmacology department of the Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, in Ribeirão Preto, São Paulo, Brazil, led by Dr. Maurício Rocha e Silva. Together with colleagues Wilson Teixeira Beraldo and Gastão Rosenfeld, they discovered the powerful hypotensive effects of bradykinin in animal preparations. Bradykinin was detected in the blood plasma of animals after the addition of venom extracted from the Bothrops jararaca (Brazilian lancehead snake), brought by Rosenfeld from the Butantan Institute. The discovery was part of a continuing study on circulatory shock and proteolytic enzymes related to the toxicology of snake bites, started by Rocha e Silva as early as 1939. Bradykinin was to prove a new autopharmacological principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active. According to B.J. Hagwood, Rocha e Silva's biographer, "The discovery of bradykinin has led to a new understanding of many physiological and pathological phenomena including circulatory shock induced by venoms and toxins." Etymology: brady [Gk] slow, kinin [Gk ] kīn(eîn) to move, set in motion, ? from the effect of snake venom on intestinal smooth muscle, which was noted to slowly contract.[25]

                      "You never know what worse luck your bad luck has saved you from."
                      -Cormac McCarthy

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