The bradykinin hypothesis

[George K]

@brenda for months I've been saying that the SARS-CoV-2 infection is NOT a respiratory illness. It's a generalized vascular illness, with the lungs being one of the targeted organs.

[89th]

Related, I find it cool we have a super computer (2nd fastest in the world) in our corner trying to fight this thing.

[Aqua Letifer]

@89th said in The bradykinin hypothesis:

Related, I find it cool we have a super computer (2nd fastest in the world) in our corner trying to fight this thing.

With the exception of the NORKs and whatever LCII they have running their missile defense, I'd say we probably have every mankind resource at our disposal to combat this.

[jon-nyc]

Except will.

[jon-nyc]

In case anybody's curious.

[George K]

Link to video

I've always pronounced it bray-dee-keye-nin. Every vowel is long other than the last "i".

[jon-nyc]

THat's what I assumed when I read it. But I googled it out of curiosity.

[brenda]

@George-K said in The bradykinin hypothesis:

@brenda for months I've been saying that the SARS-CoV-2 infection is NOT a respiratory illness. It's a generalized vascular illness, with the lungs being one of the targeted organs.

You're smarter than the super computer! At least you're faster at figuring it out.

How long until this changes the treatments for COVID-19?

[Loki]

Sounds scary as hell, yet so many people are asymptomatic and it kills very few young and healthy people. Doesn’t explain why that is so.

[Rainman]

I'd want the results double-checked by Mark's computer, just to be sure.

[mark]

@Rainman said in The bradykinin hypothesis:

I'd want the results double-checked by Mark's computer, just to be sure.

lol, I better "up the spec" to the 64 core Threadripper and 256 Gigs of Ram. What's an extra $4.5k anyway?

[Aqua Letifer]

@Loki said in The bradykinin hypothesis:

Sounds scary as hell, yet so many people are asymptomatic and it kills very few young and healthy people. Doesn’t explain why that is so.

Yes it does. If the virus fails to incite the storm, prognosis is much, much better. That's why Vitamin D is helpful.

[jon-nyc]

A most curious etymology.

From la wik:

Bradykinin was discovered in 1948 by three Brazilian physiologists and pharmacologists working at the Biochemistry and Pharmacology department of the Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, in Ribeirão Preto, São Paulo, Brazil, led by Dr. Maurício Rocha e Silva. Together with colleagues Wilson Teixeira Beraldo and Gastão Rosenfeld, they discovered the powerful hypotensive effects of bradykinin in animal preparations. Bradykinin was detected in the blood plasma of animals after the addition of venom extracted from the Bothrops jararaca (Brazilian lancehead snake), brought by Rosenfeld from the Butantan Institute. The discovery was part of a continuing study on circulatory shock and proteolytic enzymes related to the toxicology of snake bites, started by Rocha e Silva as early as 1939. Bradykinin was to prove a new autopharmacological principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active. According to B.J. Hagwood, Rocha e Silva's biographer, "The discovery of bradykinin has led to a new understanding of many physiological and pathological phenomena including circulatory shock induced by venoms and toxins." Etymology: brady [Gk] slow, kinin [Gk ] kīn(eîn) to move, set in motion, ? from the effect of snake venom on intestinal smooth muscle, which was noted to slowly contract.[25]