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The New Coffee Room

  1. TNCR
  2. General Discussion
  3. Major Covid treatment breakthrough? - Dexamethasone

Major Covid treatment breakthrough? - Dexamethasone

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  • A Offline
    A Offline
    Axtremus
    wrote on 26 Jun 2020, 19:23 last edited by
    #13

    https://www.nytimes.com/2020/06/24/health/coronavirus-dexamethasone.html

    Breakthrough Drug for Covid-19 May Be Risky for Mild Cases
    ‘That study about dexamethasone has arrived with a big asterisk: While it appears to help severely ill patients, it harms others.’

    L 1 Reply Last reply 26 Jun 2020, 19:27
    • A Axtremus
      26 Jun 2020, 19:23

      https://www.nytimes.com/2020/06/24/health/coronavirus-dexamethasone.html

      Breakthrough Drug for Covid-19 May Be Risky for Mild Cases
      ‘That study about dexamethasone has arrived with a big asterisk: While it appears to help severely ill patients, it harms others.’

      L Offline
      L Offline
      Loki
      wrote on 26 Jun 2020, 19:27 last edited by
      #14

      @Axtremus said in Major Covid treatment breakthrough? - Dexamethasone:

      https://www.nytimes.com/2020/06/24/health/coronavirus-dexamethasone.html

      Breakthrough Drug for Covid-19 May Be Risky for Mild Cases
      ‘That study about dexamethasone has arrived with a big asterisk: While it appears to help severely ill patients, it harms others.’

      Who is this for? The public not to take it without doc’s consent. The risk factors for it are very well known.

      1 Reply Last reply
      • G Offline
        G Offline
        George K
        wrote on 26 Jun 2020, 19:28 last edited by George K
        #15

        Decadron (dexamethasone) is a potent steroid - about 20 times more potent than hydrocortisone, iirc.

        Its primary effect is anti-inflammatory.

        Steroids are known to increase the risk of infection, so...

        And this:

        Dexamethasone was beneficial for those who had been sick for more than a week, reducing deaths by one-third among patients on mechanical ventilators and by one-fifth among patients receiving supplemental oxygen by other means.

        Patients given the steroid who were not receiving respiratory support, however, actually died at a slightly higher rate than similar patients who were not given the drug, although the difference was not statistically significant.

        "Now look here, you Baltic gas passer... " - Mik, 6/14/08

        The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

        1 Reply Last reply
        • L Offline
          L Offline
          LuFins Dad
          wrote on 26 Jun 2020, 19:58 last edited by
          #16

          I’m all in on Famotodine!
          https://www.medrxiv.org/content/10.1101/2020.05.01.20086694v2

          The Brad

          1 Reply Last reply
          • G Offline
            G Offline
            George K
            wrote on 23 Mar 2021, 22:26 last edited by
            #17

            Anti-inflammatory:
            Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide

            Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.

            Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.

            As Covid-19 emerged in late 2019, Oxford University’s Peter Horby, an infectious disease specialist, had begun working on Covid drug trials in Wuhan. But studies were shelved as fierce lockdown restrictions dried up infections in China. Meanwhile, cases began to pop up in Europe.

            Horby joined forces with Oxford colleague Martin Landray, a professor of medicine and epidemiology, to set up Recovery. It took them only nine days from drafting their first protocol to the enrolling of the first patient, a process that typically takes nine months.

            Less than 100 days after the programme kicked off, trial investigators produced a staggering result – the first medicine that demonstrably improved Covid-19 survival chances. Dexamethasone, a widely available and affordable generic steroid, was shown to cut the risk of death by a third for Covid patients on ventilators, and by nearly a fifth for those on oxygen therapy.

            "Now look here, you Baltic gas passer... " - Mik, 6/14/08

            The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

            J 1 Reply Last reply 23 Mar 2021, 23:40
            • R Offline
              R Offline
              Rainman
              wrote on 23 Mar 2021, 23:03 last edited by
              #18

              There was another one called ivermectin as I recall, that was touted as being a great supplement for Covid patients.

              Seems I recall the media blasting anything that Trump would say, even if it were a helpful medication.

              J 1 Reply Last reply 23 Mar 2021, 23:41
              • G George K
                23 Mar 2021, 22:26

                Anti-inflammatory:
                Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide

                Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.

                Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.

                As Covid-19 emerged in late 2019, Oxford University’s Peter Horby, an infectious disease specialist, had begun working on Covid drug trials in Wuhan. But studies were shelved as fierce lockdown restrictions dried up infections in China. Meanwhile, cases began to pop up in Europe.

                Horby joined forces with Oxford colleague Martin Landray, a professor of medicine and epidemiology, to set up Recovery. It took them only nine days from drafting their first protocol to the enrolling of the first patient, a process that typically takes nine months.

                Less than 100 days after the programme kicked off, trial investigators produced a staggering result – the first medicine that demonstrably improved Covid-19 survival chances. Dexamethasone, a widely available and affordable generic steroid, was shown to cut the risk of death by a third for Covid patients on ventilators, and by nearly a fifth for those on oxygen therapy.

                J Offline
                J Offline
                Jolly
                wrote on 23 Mar 2021, 23:40 last edited by
                #19

                @george-k said in Major Covid treatment breakthrough? - Dexamethasone:

                Anti-inflammatory:
                Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide

                Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.

                Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.

                As Covid-19 emerged in late 2019, Oxford University’s Peter Horby, an infectious disease specialist, had begun working on Covid drug trials in Wuhan. But studies were shelved as fierce lockdown restrictions dried up infections in China. Meanwhile, cases began to pop up in Europe.

                Horby joined forces with Oxford colleague Martin Landray, a professor of medicine and epidemiology, to set up Recovery. It took them only nine days from drafting their first protocol to the enrolling of the first patient, a process that typically takes nine months.

                Less than 100 days after the programme kicked off, trial investigators produced a staggering result – the first medicine that demonstrably improved Covid-19 survival chances. Dexamethasone, a widely available and affordable generic steroid, was shown to cut the risk of death by a third for Covid patients on ventilators, and by nearly a fifth for those on oxygen therapy.

                My FP guy's standard cocktail upon presentation was prednisone (I think 20mgx5days), z-pack, Pepcid, Vitamin D and Vitamin C. the wife was also offered BAM. She should have taken it, but didn't.

                “Cry havoc and let slip the DOGE of war!”

                Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton

                1 Reply Last reply
                • R Rainman
                  23 Mar 2021, 23:03

                  There was another one called ivermectin as I recall, that was touted as being a great supplement for Covid patients.

                  Seems I recall the media blasting anything that Trump would say, even if it were a helpful medication.

                  J Offline
                  J Offline
                  Jolly
                  wrote on 23 Mar 2021, 23:41 last edited by
                  #20

                  @rainman said in Major Covid treatment breakthrough? - Dexamethasone:

                  There was another one called ivermectin as I recall, that was touted as being a great supplement for Covid patients.

                  Seems I recall the media blasting anything that Trump would say, even if it were a helpful medication.

                  There were docs in Baton Rouge routinely prescribing it. Also some prescribing Plaquenil.

                  “Cry havoc and let slip the DOGE of war!”

                  Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton

                  G 1 Reply Last reply 23 Mar 2021, 23:45
                  • J Jolly
                    23 Mar 2021, 23:41

                    @rainman said in Major Covid treatment breakthrough? - Dexamethasone:

                    There was another one called ivermectin as I recall, that was touted as being a great supplement for Covid patients.

                    Seems I recall the media blasting anything that Trump would say, even if it were a helpful medication.

                    There were docs in Baton Rouge routinely prescribing it. Also some prescribing Plaquenil.

                    G Offline
                    G Offline
                    George K
                    wrote on 23 Mar 2021, 23:45 last edited by
                    #21

                    @jolly said in Major Covid treatment breakthrough? - Dexamethasone:

                    Plaquenil

                    alt text

                    "Now look here, you Baltic gas passer... " - Mik, 6/14/08

                    The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

                    1 Reply Last reply
                    • J Offline
                      J Offline
                      Jolly
                      wrote on 23 Mar 2021, 23:48 last edited by
                      #22

                      Yep.

                      Docs tend to use what they think will work, even if it's only a slim chance. Slim beats none...

                      “Cry havoc and let slip the DOGE of war!”

                      Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton

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