Major Covid treatment breakthrough? - Dexamethasone
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@Doctor-Phibes said in Major Covid treatment breakthrough? - Dexamethasone:
Donald was an American Johnson.
Nice.
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https://www.nytimes.com/2020/06/24/health/coronavirus-dexamethasone.html
Breakthrough Drug for Covid-19 May Be Risky for Mild Cases
‘That study about dexamethasone has arrived with a big asterisk: While it appears to help severely ill patients, it harms others.’ -
@Axtremus said in Major Covid treatment breakthrough? - Dexamethasone:
https://www.nytimes.com/2020/06/24/health/coronavirus-dexamethasone.html
Breakthrough Drug for Covid-19 May Be Risky for Mild Cases
‘That study about dexamethasone has arrived with a big asterisk: While it appears to help severely ill patients, it harms others.’Who is this for? The public not to take it without doc’s consent. The risk factors for it are very well known.
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Decadron (dexamethasone) is a potent steroid - about 20 times more potent than hydrocortisone, iirc.
Its primary effect is anti-inflammatory.
Steroids are known to increase the risk of infection, so...
And this:
Dexamethasone was beneficial for those who had been sick for more than a week, reducing deaths by one-third among patients on mechanical ventilators and by one-fifth among patients receiving supplemental oxygen by other means.
Patients given the steroid who were not receiving respiratory support, however, actually died at a slightly higher rate than similar patients who were not given the drug, although the difference was not statistically significant.
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I’m all in on Famotodine!
https://www.medrxiv.org/content/10.1101/2020.05.01.20086694v2 -
Anti-inflammatory:
Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide
Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.
Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.
As Covid-19 emerged in late 2019, Oxford University’s Peter Horby, an infectious disease specialist, had begun working on Covid drug trials in Wuhan. But studies were shelved as fierce lockdown restrictions dried up infections in China. Meanwhile, cases began to pop up in Europe.
Horby joined forces with Oxford colleague Martin Landray, a professor of medicine and epidemiology, to set up Recovery. It took them only nine days from drafting their first protocol to the enrolling of the first patient, a process that typically takes nine months.
Less than 100 days after the programme kicked off, trial investigators produced a staggering result – the first medicine that demonstrably improved Covid-19 survival chances. Dexamethasone, a widely available and affordable generic steroid, was shown to cut the risk of death by a third for Covid patients on ventilators, and by nearly a fifth for those on oxygen therapy.
"Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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@george-k said in Major Covid treatment breakthrough? - Dexamethasone:
Anti-inflammatory:
Dexamethasone hailed as lifesaver for up to a million Covid patients worldwide
Dexamethasone – the inexpensive steroid that quickly emerged as a highly effective Covid therapy thanks to a large drug testing programme pioneered by UK scientists – has so far saved the lives of an estimated million people globally, including 22,000 in the UK, according to NHS England.
Called Recovery, the world’s largest randomised Covid-19 drug trial commenced in March 2020 to evaluate the suitability of a suite of different drugs to help hospitalised Covid patients. The study has since been carried out by thousands of doctors and nurses on tens of thousands of patients in hospitals across Britain.
As Covid-19 emerged in late 2019, Oxford University’s Peter Horby, an infectious disease specialist, had begun working on Covid drug trials in Wuhan. But studies were shelved as fierce lockdown restrictions dried up infections in China. Meanwhile, cases began to pop up in Europe.
Horby joined forces with Oxford colleague Martin Landray, a professor of medicine and epidemiology, to set up Recovery. It took them only nine days from drafting their first protocol to the enrolling of the first patient, a process that typically takes nine months.
Less than 100 days after the programme kicked off, trial investigators produced a staggering result – the first medicine that demonstrably improved Covid-19 survival chances. Dexamethasone, a widely available and affordable generic steroid, was shown to cut the risk of death by a third for Covid patients on ventilators, and by nearly a fifth for those on oxygen therapy.
My FP guy's standard cocktail upon presentation was prednisone (I think 20mgx5days), z-pack, Pepcid, Vitamin D and Vitamin C. the wife was also offered BAM. She should have taken it, but didn't.
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@rainman said in Major Covid treatment breakthrough? - Dexamethasone:
There was another one called ivermectin as I recall, that was touted as being a great supplement for Covid patients.
Seems I recall the media blasting anything that Trump would say, even if it were a helpful medication.
There were docs in Baton Rouge routinely prescribing it. Also some prescribing Plaquenil.
Always remember, Operation Valkyrie was an act of sedition.
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