Skip to content
  • Categories
  • Recent
  • Tags
  • Popular
  • Users
  • Groups
Skins
  • Light
  • Cerulean
  • Cosmo
  • Flatly
  • Journal
  • Litera
  • Lumen
  • Lux
  • Materia
  • Minty
  • Morph
  • Pulse
  • Sandstone
  • Simplex
  • Sketchy
  • Spacelab
  • United
  • Yeti
  • Zephyr
  • Dark
  • Cyborg
  • Darkly
  • Quartz
  • Slate
  • Solar
  • Superhero
  • Vapor

  • Default (No Skin)
  • No Skin
Collapse

The New Coffee Room

  1. TNCR
  2. General Discussion
  3. I am a bioinformatician

I am a bioinformatician

Scheduled Pinned Locked Moved General Discussion
19 Posts 12 Posters 124 Views
  • Oldest to Newest
  • Newest to Oldest
  • Most Votes
Reply
  • Reply as topic
Log in to reply
This topic has been deleted. Only users with topic management privileges can see it.
  • HoraceH Offline
    HoraceH Offline
    Horace
    wrote on last edited by
    #1

    I recently moved from the software development group into the bioinformatics group. Since I was doing bioinformatics for this company since before they had a bioinformatics department, and since I had no interest in writing UI code for the rest of my career, I requested and was granted this transfer. Now all my peers are math/bioinformatics PhDs and my boss is a math/physics PhD from Harvard. Recently my company has been trying to release a covid virus assay for use with our ddPcr instrument and I was chosen to lead the effort to develop the algorithms and tools to process the data and call results. Mayo will be our first customer, who plan on running 3000 samples/day through this analysis tool. We're also working with Johns Hopkins apparently. It will hopefully be released within a couple weeks, but now we're running into issues with the assay which will be show stoppers if not fixed.

    Education is extremely important.

    1 Reply Last reply
    • MikM Away
      MikM Away
      Mik
      wrote on last edited by
      #2

      What a great development for you, and for us.

      “I am fond of pigs. Dogs look up to us. Cats look down on us. Pigs treat us as equals.” ~Winston S. Churchill

      1 Reply Last reply
      • brendaB Offline
        brendaB Offline
        brenda
        wrote on last edited by
        #3

        Thank you for your work, Horace! If you make a visit to Mayo, let me know.

        HoraceH 1 Reply Last reply
        • L Offline
          L Offline
          Loki
          wrote on last edited by
          #4

          I’ll never accuse Horace of not understanding how science works!

          HoraceH 1 Reply Last reply
          • jon-nycJ Offline
            jon-nycJ Offline
            jon-nyc
            wrote on last edited by
            #5

            That’s cool.

            Only non-witches get due process.

            • Cotton Mather, Salem Massachusetts, 1692
            1 Reply Last reply
            • LuFins DadL Offline
              LuFins DadL Offline
              LuFins Dad
              wrote on last edited by
              #6

              Looking forward to updates!

              The Brad

              1 Reply Last reply
              • L Loki

                I’ll never accuse Horace of not understanding how science works!

                HoraceH Offline
                HoraceH Offline
                Horace
                wrote on last edited by
                #7

                @Loki said in I am a bioinformatician:

                I’ll never accuse Horace of not understanding how science works!

                I know exactly how quick and dirty science works.

                Education is extremely important.

                1 Reply Last reply
                • brendaB brenda

                  Thank you for your work, Horace! If you make a visit to Mayo, let me know.

                  HoraceH Offline
                  HoraceH Offline
                  Horace
                  wrote on last edited by
                  #8

                  @brenda said in I am a bioinformatician:

                  Thank you for your work, Horace! If you make a visit to Mayo, let me know.

                  The way it works is, I create the tool, explain to the marketing folk what the tool does, and then they present it to our users. I never so much as see them on a video call, so I don't anticipate any travel. However I have been interacting with company higher-ups through this project so that's been a rare treat.

                  Education is extremely important.

                  brendaB 1 Reply Last reply
                  • Aqua LetiferA Offline
                    Aqua LetiferA Offline
                    Aqua Letifer
                    wrote on last edited by
                    #9

                    Yeah okay. And now I'm a mathematologist.

                    Seriously though, sounds cool.

                    Please love yourself.

                    1 Reply Last reply
                    • George KG Offline
                      George KG Offline
                      George K
                      wrote on last edited by
                      #10

                      Good for you!

                      "Now look here, you Baltic gas passer... " - Mik, 6/14/08

                      The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

                      1 Reply Last reply
                      • 89th8 Offline
                        89th8 Offline
                        89th
                        wrote on last edited by
                        #11

                        Cool update, interesting work!

                        1 Reply Last reply
                        • taiwan_girlT Offline
                          taiwan_girlT Offline
                          taiwan_girl
                          wrote on last edited by
                          #12

                          👍

                          1 Reply Last reply
                          • KlausK Offline
                            KlausK Offline
                            Klaus
                            wrote on last edited by
                            #13

                            Sounds cool! What, more specifically, is your job? Do you write the algorithms yourself? What kinds of algorithms are these?

                            1 Reply Last reply
                            • HoraceH Offline
                              HoraceH Offline
                              Horace
                              wrote on last edited by
                              #14

                              In this case the algorithms we needed were a clustering algorithm and an algorithm to detect messy data so we don't provide a false positive or false negative. I write them myself, though the reason they had me do it was because they needed to be written very quickly and I've been going around my whole career telling people I can write algorithms. I have in fact been given that opportunity on occasion, and now that I'm in bioinformatics it won't be politically difficult to be more involved in that stuff.

                              Education is extremely important.

                              1 Reply Last reply
                              • KlausK Offline
                                KlausK Offline
                                Klaus
                                wrote on last edited by
                                #15

                                Aren't libraries containing these kinds of algorithms readily available? Why do you bother to write them yourself?

                                HoraceH 1 Reply Last reply
                                • HoraceH Horace

                                  @brenda said in I am a bioinformatician:

                                  Thank you for your work, Horace! If you make a visit to Mayo, let me know.

                                  The way it works is, I create the tool, explain to the marketing folk what the tool does, and then they present it to our users. I never so much as see them on a video call, so I don't anticipate any travel. However I have been interacting with company higher-ups through this project so that's been a rare treat.

                                  brendaB Offline
                                  brendaB Offline
                                  brenda
                                  wrote on last edited by
                                  #16

                                  @Horace said in I am a bioinformatician:

                                  @brenda said in I am a bioinformatician:

                                  Thank you for your work, Horace! If you make a visit to Mayo, let me know.

                                  The way it works is, I create the tool, explain to the marketing folk what the tool does, and then they present it to our users. I never so much as see them on a video call, so I don't anticipate any travel. However I have been interacting with company higher-ups through this project so that's been a rare treat.

                                  Well, if they're not Minnesooota nice to you, let me know. I'll get them in line to behave again.

                                  1 Reply Last reply
                                  • KlausK Klaus

                                    Aren't libraries containing these kinds of algorithms readily available? Why do you bother to write them yourself?

                                    HoraceH Offline
                                    HoraceH Offline
                                    Horace
                                    wrote on last edited by
                                    #17

                                    @Klaus said in I am a bioinformatician:

                                    Aren't libraries containing these kinds of algorithms readily available? Why do you bother to write them yourself?

                                    I would be happy to place any bet on my custom written algorithm to solve these particular problems on this particular data against any standard out of the box algorithm. We do have someone in the bioinformatics group working on a machine learning approach to clustering this sort of data, she has been working on that for many months now, but when it came to this need for this algorithm to be delivered to a customer in very short time, they asked me to do it.

                                    Education is extremely important.

                                    1 Reply Last reply
                                    • HoraceH Offline
                                      HoraceH Offline
                                      Horace
                                      wrote on last edited by
                                      #18

                                      I did end up independently inventing Mahalanobis_distance in the couple days I spent thinking about and implementing this algorithm. I described what I was doing to my boss and he told me it had a name.

                                      Education is extremely important.

                                      1 Reply Last reply
                                      • JollyJ Offline
                                        JollyJ Offline
                                        Jolly
                                        wrote on last edited by
                                        #19

                                        Interesting work that makes a difference.

                                        Can't ask for much more than that...

                                        “Cry havoc and let slip the DOGE of war!”

                                        Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton

                                        1 Reply Last reply
                                        Reply
                                        • Reply as topic
                                        Log in to reply
                                        • Oldest to Newest
                                        • Newest to Oldest
                                        • Most Votes


                                        • Login

                                        • Don't have an account? Register

                                        • Login or register to search.
                                        • First post
                                          Last post
                                        0
                                        • Categories
                                        • Recent
                                        • Tags
                                        • Popular
                                        • Users
                                        • Groups