Omicron variant: Move over, Delta
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Moderna CEO expects material drop in Moderna vaccine’s effectiveness against the Omicron variant.
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@axtremus said in Move over, Delta:
Moderna CEO expects material drop in Moderna vaccine’s effectiveness against the Omicron variant.
At this point in time, he's blowing smoke out of his ass.
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@George-K Reminds me of @bachophile post about spread vs seriousness of disease… This may be less serious on average, but if it’s spread is wider it could be far worse than Delta.
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@Jolly I would think that they could look at the particular spike proteins their particular vaccine targets and be able to say “oh
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Dr. Uğur Şahin—the co-founder of BioNTech who helped develop Pfizer’s mRNA COVID-19 vaccine—told The Wall Street Journal Tuesday that, even if the Omicron variant leads to more breakthrough COVID-19 infections, he believes the vaccines will continue to protect against severe disease. “If a virus achieves immune escape, it achieves it against antibodies, but there is the second level of immune response that protects from severe disease—the T-cells,” he said.
The European Centre for Disease Prevention and Control said yesterday that as of Tuesday morning, 44 Omicron variant cases had been confirmed by 11 European countries and that “all cases for which there is information available on severity were either asymptomatic or had mild symptoms.”
DON’T let them eat cake.
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@jon-nyc said in Move over, Delta:
Dr. Uğur Şahin—the co-founder of BioNTech who helped develop Pfizer’s mRNA COVID-19 vaccine—told The Wall Street Journal Tuesday that, even if the Omicron variant leads to more breakthrough COVID-19 infections, he believes the vaccines will continue to protect against severe disease. “If a virus achieves immune escape, it achieves it against antibodies, but there is the second level of immune response that protects from severe disease—the T-cells,” he said.
IOW, he believes the Nu variant of Wuhan COVID -Xi 19 achieves immune escape against the current virus but they are hoping that the T-Cells will save the day. The question I have is if the T-Cells are working on the same recognition patterns as the antibodies, why do they think it will work? The ID of the spike proteins had to be very specific as there are necessary and beneficial spike proteins that you do not want to mess with. It’s a big part of the concern with the Merck pill. They have seen examples of stillborn and birth defects when administered to pregnant animals.
https://www.latimes.com/science/story/2021-11-29/fda-merck-covid-pill-effective-but-flags-safety-concerns-pregnant-women -
@jon-nyc said in Move over, Delta:
The European Centre for Disease Prevention and Control said yesterday that as of Tuesday morning, 44 Omicron variant cases had been confirmed by 11 European countries and that “all cases for which there is information available on severity were either asymptomatic or had mild symptoms.”
That would be the same number with Delta or even Alpha.
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@lufins-dad said in Move over, Delta:
@jon-nyc said in Move over, Delta:
Dr. Uğur Şahin—the co-founder of BioNTech who helped develop Pfizer’s mRNA COVID-19 vaccine—told The Wall Street Journal Tuesday that, even if the Omicron variant leads to more breakthrough COVID-19 infections, he believes the vaccines will continue to protect against severe disease. “If a virus achieves immune escape, it achieves it against antibodies, but there is the second level of immune response that protects from severe disease—the T-cells,” he said.
IOW, he believes the Nu variant of Wuhan COVID -Xi 19 achieves immune escape against the current virus but they are hoping that the T-Cells will save the day. The question I have is if the T-Cells are working on the same recognition patterns as the antibodies, why do they think it will work? The ID of the spike proteins had to be very specific as there are necessary and beneficial spike proteins that you do not want to mess with. It’s a big part of the concern with the Merck pill. They have seen examples of stillborn and birth defects when administered to pregnant animals.
https://www.latimes.com/science/story/2021-11-29/fda-merck-covid-pill-effective-but-flags-safety-concerns-pregnant-womenLast study I saw, T-cells had at least eight months response. I suspect it's more.
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@lufins-dad said in Move over, Delta:
@jon-nyc said in Move over, Delta:
Dr. Uğur Şahin—the co-founder of BioNTech who helped develop Pfizer’s mRNA COVID-19 vaccine—told The Wall Street Journal Tuesday that, even if the Omicron variant leads to more breakthrough COVID-19 infections, he believes the vaccines will continue to protect against severe disease. “If a virus achieves immune escape, it achieves it against antibodies, but there is the second level of immune response that protects from severe disease—the T-cells,” he said.
IOW, he believes the Nu variant of Wuhan COVID -Xi 19 achieves immune escape against the current virus but they are hoping that the T-Cells will save the day. The question I have is if the T-Cells are working on the same recognition patterns as the antibodies, why do they think it will work? The ID of the spike proteins had to be very specific as there are necessary and beneficial spike proteins that you do not want to mess with. It’s a big part of the concern with the Merck pill. They have seen examples of stillborn and birth defects when administered to pregnant animals.
https://www.latimes.com/science/story/2021-11-29/fda-merck-covid-pill-effective-but-flags-safety-concerns-pregnant-womenAntibodies and T cells are entirely different in terms of their jobs and how they do it.
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@aqua-letifer I get that, but the T-Cells still need to recognize the spike proteins on the infected cells in order to attack them. If they aren’t recognizing the proteins, then they are going to be less effective.
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@jolly said in Move over, Delta:
@lufins-dad said in Move over, Delta:
@jon-nyc said in Move over, Delta:
Dr. Uğur Şahin—the co-founder of BioNTech who helped develop Pfizer’s mRNA COVID-19 vaccine—told The Wall Street Journal Tuesday that, even if the Omicron variant leads to more breakthrough COVID-19 infections, he believes the vaccines will continue to protect against severe disease. “If a virus achieves immune escape, it achieves it against antibodies, but there is the second level of immune response that protects from severe disease—the T-cells,” he said.
IOW, he believes the Nu variant of Wuhan COVID -Xi 19 achieves immune escape against the current virus but they are hoping that the T-Cells will save the day. The question I have is if the T-Cells are working on the same recognition patterns as the antibodies, why do they think it will work? The ID of the spike proteins had to be very specific as there are necessary and beneficial spike proteins that you do not want to mess with. It’s a big part of the concern with the Merck pill. They have seen examples of stillborn and birth defects when administered to pregnant animals.
https://www.latimes.com/science/story/2021-11-29/fda-merck-covid-pill-effective-but-flags-safety-concerns-pregnant-womenLast study I saw, T-cells had at least eight months response. I suspect it's more.
It’s not a matter of duration, they still need to recognize and attack the infected cells no recognition, no attack.
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OMG! OMC was in the NYC at the NMA!
