Why you stay fat
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wrote on 20 Nov 2024, 14:27 last edited by
"The Yo-Yo effect of weight loss is explained by the fact that Fluffy cells, sickly, remember how to be Fluffy and have a likelihood to try to be Fluffy again.
Epigenetic memory refers to how cells exhibit a form of "memory" through changes in gene expression that do not alter the DNA sequence itself but rather how genes are read or expressed.
The existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic 'yo-yo' effect often seen with dieting."
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wrote on 20 Nov 2024, 14:32 last edited by
I don't quite understand how this is supposed to work.
The body can't make fat out of thin air.
Unless you eat more than you burn, you won't get fat.
So you'd only get fatter if either that "memory" somehow causes you to eat more, or somehow causes you to burn less.
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"The Yo-Yo effect of weight loss is explained by the fact that Fluffy cells, sickly, remember how to be Fluffy and have a likelihood to try to be Fluffy again.
Epigenetic memory refers to how cells exhibit a form of "memory" through changes in gene expression that do not alter the DNA sequence itself but rather how genes are read or expressed.
The existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic 'yo-yo' effect often seen with dieting."
wrote on 20 Nov 2024, 14:46 last edited by@George-K said in Why you stay fat:
The existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes ....
the problematic 'yo-yo' effect....
I'm impressed the author was able to use such a wide spectrum of words in this paragraph.
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I don't quite understand how this is supposed to work.
The body can't make fat out of thin air.
Unless you eat more than you burn, you won't get fat.
So you'd only get fatter if either that "memory" somehow causes you to eat more, or somehow causes you to burn less.
wrote on 20 Nov 2024, 14:58 last edited by@Klaus said in Why you stay fat:
I don't quite understand how this is supposed to work.
The body can't make fat out of thin air.
Unless you eat more than you burn, you won't get fat.
So you'd only get fatter if either that "memory" somehow causes you to eat more, or somehow causes you to burn less.
Without reading the study, I'd say that the fat cells are more efficient at converting any extra calories above the ketoric state into fat.