Skip to content
  • Categories
  • Recent
  • Tags
  • Popular
  • Users
  • Groups
Skins
  • Light
  • Cerulean
  • Cosmo
  • Flatly
  • Journal
  • Litera
  • Lumen
  • Lux
  • Materia
  • Minty
  • Morph
  • Pulse
  • Sandstone
  • Simplex
  • Sketchy
  • Spacelab
  • United
  • Yeti
  • Zephyr
  • Dark
  • Cyborg
  • Darkly
  • Quartz
  • Slate
  • Solar
  • Superhero
  • Vapor

  • Default (No Skin)
  • No Skin
Collapse

The New Coffee Room

  1. TNCR
  2. General Discussion
  3. Backward after COVID in CHina

Backward after COVID in CHina

Scheduled Pinned Locked Moved General Discussion
7 Posts 4 Posters 44 Views
  • Oldest to Newest
  • Newest to Oldest
  • Most Votes
Reply
  • Reply as topic
Log in to reply
This topic has been deleted. Only users with topic management privileges can see it.
  • George KG Offline
    George KG Offline
    George K
    wrote on last edited by
    #1

    https://www.nejm.org/doi/full/10.1056/NEJMc2309215

    Association of SARS-CoV-2 Infection during Early Weeks of Gestation with Situs Inversus

    Situs inversus, including situs inversus totalis (with dextrocardia) and partial situs inversus (with levocardia), is a rare congenital condition in which visceral organization is inverted as compared with normal organ development. We noted a striking increase in the number of cases of fetal situs inversus that were diagnosed by means of ultrasonography at our hospital several months after the “zero-Covid” policies in China were lifted.

    image.jpeg

    We determined the incidence of fetal situs inversus from January 2014 through July 2023 using clinical data from two obstetrical centers in different regions of China. During the first 7 months of 2023, the incidence of situs inversus (diagnosed by means of routine ultrasonography at a gestational age of approximately 20 to 24 weeks, with no change having been made in the diagnostic protocol or physician training) at these centers was over four times as high as the mean annual incidence from 2014 through 2022 (Figure 1 and Fig. S1 and Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org); the incidence peaked in April 2023 and remained elevated through June 2023. Overall, 56 cases of situs inversus were identified from January 2023 through July 2023 (52 cases of situs inversus totalis and 4 cases of partial situs inversus). The increase followed the surge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections that occurred after the zero-Covid policies were discontinued; this surge, which ultimately was estimated to affect approximately 82% of the population in China, began in early December 2022, peaked around December 20, 2022, and ended in early February 2023.1 Although no conclusions can be made regarding causality, our observations suggest a possible relationship between SARS-CoV-2 infection and fetal situs inversus that warrants further study.

    Congenital situs inversus has been linked to aberrant morphogen distribution and cilia dysfunction of the left–right organizer in visceral lateralization during the early weeks of gestation.2 Although vertical transmission of SARS-CoV-2 is debated,3 fetal infection early in gestation could hypothetically affect visceral lateralization; alternatively, SARS-CoV-2–mediated maternal inflammatory responses4,5 might indirectly affect left–right organizer function and impair visceral lateralization. Further analysis is necessary to verify that genetic abnormalities in primary ciliary dyskinesia–related genes that may not have been detected during prenatal genetic screening did not contribute to the incidence of these cases and to assess the potential contribution of environmental factors. It is notable that situs inversus diagnoses remained extremely rare despite the increase in incidence at our centers after the SARS-CoV-2 surge.

    "Now look here, you Baltic gas passer... " - Mik, 6/14/08

    The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

    1 Reply Last reply
    • JollyJ Offline
      JollyJ Offline
      Jolly
      wrote on last edited by
      #2

      Well...being that this is genetic, what are we saying?

      “Cry havoc and let slip the DOGE of war!”

      Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton

      1 Reply Last reply
      • taiwan_girlT Offline
        taiwan_girlT Offline
        taiwan_girl
        wrote on last edited by
        #3

        @George-K

        Can you translate into special English? 😅

        1 Reply Last reply
        • George KG Offline
          George KG Offline
          George K
          wrote on last edited by
          #4

          Situs inversus is a rare condition (1/10,000) in which everything in your body is on the opposite side of where it should be. For example, the liver is on the left side, as is the appendix. I've never seen it.

          https://en.wikipedia.org/wiki/Situs_inversus

          The point of this report is that there was a spike (pun intended) in the incidence of situs inversus in China during COVID.

          "Now look here, you Baltic gas passer... " - Mik, 6/14/08

          The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

          1 Reply Last reply
          • AxtremusA Offline
            AxtremusA Offline
            Axtremus
            wrote on last edited by
            #5

            Just curious, aside from COVID, is situs inversus correlated with other health issues like diseases or disabilities?

            George KG 1 Reply Last reply
            • AxtremusA Axtremus

              Just curious, aside from COVID, is situs inversus correlated with other health issues like diseases or disabilities?

              George KG Offline
              George KG Offline
              George K
              wrote on last edited by
              #6

              @Axtremus said in Backward after COVID in CHina:

              Just curious, aside from COVID, is situs inversus correlated with other health issues like diseases or disabilities?

              The Wiki link I posted will tell you everything you want to know.

              "Now look here, you Baltic gas passer... " - Mik, 6/14/08

              The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

              1 Reply Last reply
              • AxtremusA Offline
                AxtremusA Offline
                Axtremus
                wrote on last edited by Axtremus
                #7

                Yeah, this mostly answers my question:

                … situs inversus rarely causes any additional symptoms.

                1 Reply Last reply
                Reply
                • Reply as topic
                Log in to reply
                • Oldest to Newest
                • Newest to Oldest
                • Most Votes


                • Login

                • Don't have an account? Register

                • Login or register to search.
                • First post
                  Last post
                0
                • Categories
                • Recent
                • Tags
                • Popular
                • Users
                • Groups