I've been asked to take an experimental COVID vaccine
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One of the companies that is working on a COVID vaccine is in my hometown (Curevac).
I fit into the (rather narrow) criteria of test persons they are seeking.
In total I'd have to show up 12 times; two times to get a vaccine shot and 10 times for checking things. They'd pay me 1300 Euro.
Would you agree?
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Over here the FDA conducts a graduated set of clinical trials, each successive one being larger, and (I think) with each time a more refined product. (Jon would know more. LOTS more.) Is that how it works over there? If so, whereabouts in the program would your trial be?
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I would be open to it. It’s probably a p1 test where they are still testing different doses and you may get a placebo but I would be open to it.
I would have questions about study design and the technology used, but I would at least show up.
Oddly I couldn’t find it here, where I always find clinical trials in the EU. They have several cancer vaccine trials registered.
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Yep.
The Phase 1 dose escalation trial will assess a dose range of 2µg to 8µg in 168 healthy volunteers aged 18 to 60 years. The objective is to establish the optimal dose while investigating the safety and immune profile of the vaccine candidate.
https://www.clinicaltrialsarena.com/news/curevac-covid-19-vaccine-trial/
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It doesn’t mention placebo but it’s just a press piece. Once it’s registered you can see the relative sizes of each study arm to assess your odds of getting which dose and/or placebo.
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From another piece about Curevac:
In countries where SARS-CoV-2 is less prevalent, such as Germany, trial participants will be less likely to come into contact with the virus; by extension, it will take studies longer to generate efficacy data. The time-pressured nature of COVID-19 vaccine development is leading companies to try to avoid such delays, for example by enrolling healthcare professionals and other groups more likely to be exposed to the coronavirus in efficacy studies.
I wonder if being a family member of a healthcare provider makes you a more attractive candidate (I obviously meant that only figuratively).
Again, once it’s registered, you will see inclusion and exclusion criteria spelled out.
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@jon-nyc said in I've been asked to take an experimental COVID vaccine:
Yep.
The Phase 1 dose escalation trial will assess a dose range of 2µg to 8µg in 168 healthy volunteers aged 18 to 60 years. The objective is to establish the optimal dose while investigating the safety and immune profile of the vaccine candidate.
https://www.clinicaltrialsarena.com/news/curevac-covid-19-vaccine-trial/
Interesting. The criteria mentioned in the email I received are more narrow (41-60 years, BMI restrictions) but otherwise it sounds like the same study.
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@jon-nyc said in I've been asked to take an experimental COVID vaccine:
I would be open to it. It’s probably a p1 test where they are still testing different doses and you may get a placebo but I would be open to it.
I would have questions about study design and the technology used, but I would at least show up.
Oddly I couldn’t find it here, where I always find clinical trials in the EU. They have several cancer vaccine trials registered.
scratch that, looks like a rabies vaccine
aha found the right one now
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i would do it...but then again see my other thread and im not sure i need to be such a hero.
i guess im waiting for the moderna or oxford/astrazenica to become available
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Now I received a document with way more information about the study.
If I'd participate, I'd have a 20% chance of being in the placebo group. The other groups get different amounts of the vaccine.
All in all, it sounds rather time-consuming to participate. So many examinations. So much paperwork. I think I'll let this pass.
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I think I am inclined to participate in a vaccine trial for COVID-19, but like Klaus, I would want to weigh whatever information I can get to (1) get a sense of whether I can trust the people running the trial, (2) whether I would feel "safe enough" to take the vaccine, (3) whether I can give them the time they need to conduct the trial properly.
