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The New Coffee Room

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  3. I've been asked to take an experimental COVID vaccine

I've been asked to take an experimental COVID vaccine

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  • K Online
    K Online
    Klaus
    wrote on 20 Jul 2020, 18:02 last edited by Klaus
    #1

    One of the companies that is working on a COVID vaccine is in my hometown (Curevac).

    I fit into the (rather narrow) criteria of test persons they are seeking.

    In total I'd have to show up 12 times; two times to get a vaccine shot and 10 times for checking things. They'd pay me 1300 Euro.

    Would you agree?

    1 Reply Last reply
    • C Offline
      C Offline
      Copper
      wrote on 20 Jul 2020, 18:06 last edited by
      #2

      Is this going to be one of those vaccines that cause autism?

      1 Reply Last reply
      • L Offline
        L Offline
        Loki
        wrote on 20 Jul 2020, 18:07 last edited by Loki
        #3

        What are they testing for? If only safety I wouldn’t bother. If does it work that is a different question.

        I would if it increased my odds significantly (Meaning that is the hope) that I wouldn’t get Covid.

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        • C Offline
          C Offline
          Catseye3
          wrote on 20 Jul 2020, 18:10 last edited by Catseye3
          #4

          Over here the FDA conducts a graduated set of clinical trials, each successive one being larger, and (I think) with each time a more refined product. (Jon would know more. LOTS more.) Is that how it works over there? If so, whereabouts in the program would your trial be?

          Success is measured by your discipline and inner peace. – Mike Ditka

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          • J Offline
            J Offline
            jon-nyc
            wrote on 20 Jul 2020, 18:21 last edited by jon-nyc
            #5

            I would be open to it. It’s probably a p1 test where they are still testing different doses and you may get a placebo but I would be open to it.

            I would have questions about study design and the technology used, but I would at least show up.

            Oddly I couldn’t find it here, where I always find clinical trials in the EU. They have several cancer vaccine trials registered.

            https://www.clinicaltrialsregister.eu

            Thank you for your attention to this matter.

            B 1 Reply Last reply 20 Jul 2020, 19:36
            • H Offline
              H Offline
              Horace
              wrote on 20 Jul 2020, 18:24 last edited by Horace
              #6

              I'd do it as a civic duty thing if my participation actually mattered to their ability to get the results they were looking for. But if someone more interested in the money than I would rather have that spot, then I'd gladly let them have it.

              Education is extremely important.

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              • J Offline
                J Offline
                jon-nyc
                wrote on 20 Jul 2020, 18:25 last edited by
                #7

                Yep.

                The Phase 1 dose escalation trial will assess a dose range of 2µg to 8µg in 168 healthy volunteers aged 18 to 60 years. The objective is to establish the optimal dose while investigating the safety and immune profile of the vaccine candidate.

                https://www.clinicaltrialsarena.com/news/curevac-covid-19-vaccine-trial/

                Thank you for your attention to this matter.

                K 1 Reply Last reply 20 Jul 2020, 19:24
                • J Offline
                  J Offline
                  jon-nyc
                  wrote on 20 Jul 2020, 18:27 last edited by jon-nyc
                  #8

                  It doesn’t mention placebo but it’s just a press piece. Once it’s registered you can see the relative sizes of each study arm to assess your odds of getting which dose and/or placebo.

                  Thank you for your attention to this matter.

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                  • J Offline
                    J Offline
                    jon-nyc
                    wrote on 20 Jul 2020, 18:33 last edited by jon-nyc
                    #9

                    From another piece about Curevac:

                    In countries where SARS-CoV-2 is less prevalent, such as Germany, trial participants will be less likely to come into contact with the virus; by extension, it will take studies longer to generate efficacy data. The time-pressured nature of COVID-19 vaccine development is leading companies to try to avoid such delays, for example by enrolling healthcare professionals and other groups more likely to be exposed to the coronavirus in efficacy studies.

                    I wonder if being a family member of a healthcare provider makes you a more attractive candidate (I obviously meant that only figuratively).

                    Again, once it’s registered, you will see inclusion and exclusion criteria spelled out.

                    Thank you for your attention to this matter.

                    1 Reply Last reply
                    • J jon-nyc
                      20 Jul 2020, 18:25

                      Yep.

                      The Phase 1 dose escalation trial will assess a dose range of 2µg to 8µg in 168 healthy volunteers aged 18 to 60 years. The objective is to establish the optimal dose while investigating the safety and immune profile of the vaccine candidate.

                      https://www.clinicaltrialsarena.com/news/curevac-covid-19-vaccine-trial/

                      K Online
                      K Online
                      Klaus
                      wrote on 20 Jul 2020, 19:24 last edited by
                      #10

                      @jon-nyc said in I've been asked to take an experimental COVID vaccine:

                      Yep.

                      The Phase 1 dose escalation trial will assess a dose range of 2µg to 8µg in 168 healthy volunteers aged 18 to 60 years. The objective is to establish the optimal dose while investigating the safety and immune profile of the vaccine candidate.

                      https://www.clinicaltrialsarena.com/news/curevac-covid-19-vaccine-trial/

                      Interesting. The criteria mentioned in the email I received are more narrow (41-60 years, BMI restrictions) but otherwise it sounds like the same study.

                      1 Reply Last reply
                      • J jon-nyc
                        20 Jul 2020, 18:21

                        I would be open to it. It’s probably a p1 test where they are still testing different doses and you may get a placebo but I would be open to it.

                        I would have questions about study design and the technology used, but I would at least show up.

                        Oddly I couldn’t find it here, where I always find clinical trials in the EU. They have several cancer vaccine trials registered.

                        https://www.clinicaltrialsregister.eu

                        B Offline
                        B Offline
                        bachophile
                        wrote on 20 Jul 2020, 19:36 last edited by bachophile
                        #11

                        @jon-nyc said in I've been asked to take an experimental COVID vaccine:

                        I would be open to it. It’s probably a p1 test where they are still testing different doses and you may get a placebo but I would be open to it.

                        I would have questions about study design and the technology used, but I would at least show up.

                        Oddly I couldn’t find it here, where I always find clinical trials in the EU. They have several cancer vaccine trials registered.

                        https://www.clinicaltrialsregister.eu

                        scratch that, looks like a rabies vaccine

                        aha found the right one now

                        https://clinicaltrials.gov/ct2/show/NCT04449276

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                        • B Offline
                          B Offline
                          bachophile
                          wrote on 20 Jul 2020, 19:38 last edited by
                          #12

                          i would do it...but then again see my other thread and im not sure i need to be such a hero.

                          i guess im waiting for the moderna or oxford/astrazenica to become available

                          1 Reply Last reply
                          • K Online
                            K Online
                            Klaus
                            wrote on 21 Jul 2020, 12:16 last edited by
                            #13

                            Now I received a document with way more information about the study.

                            If I'd participate, I'd have a 20% chance of being in the placebo group. The other groups get different amounts of the vaccine.

                            All in all, it sounds rather time-consuming to participate. So many examinations. So much paperwork. I think I'll let this pass.

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                            • A Offline
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                              Axtremus
                              wrote on 21 Jul 2020, 13:47 last edited by
                              #14

                              I think I am inclined to participate in a vaccine trial for COVID-19, but like Klaus, I would want to weigh whatever information I can get to (1) get a sense of whether I can trust the people running the trial, (2) whether I would feel "safe enough" to take the vaccine, (3) whether I can give them the time they need to conduct the trial properly.

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