Schizophrenia Genes Identified
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Scientists have identified two new genes linked to schizophrenia and discovered that a third gene previously known to be involved in the disorder may also play a role in autism.
The genes were identified through a meta-analysis comparing gene sequences of 35,828 people with schizophrenia to 107,877 people without the condition.
The study builds on a report published last year that identified 10 genes with rare variants that are directly tied to schizophrenia risk. But that study, like most prior genetic analyses on psychiatric illnesses, was done on the DNA from people of European ancestry.
About 40% of the genetic samples included in this new work came from people of non-European ancestry, which researchers say makes it the most ethnically diverse schizophrenia genetics study to date.
Based on the findings, researchers concluded that the schizophrenia risk conferred by the rare genetic variants found on the new genes they discovered and on those previously identified is conserved across ethnicities.
The new genes, SRRM2 and AKAP11, contain rare protein-truncating variants (PTVs) that investigators say could be the cause of schizophrenia in some patients. The results could have significant implications for drug development. -
Hilariously enough, there's a history of this in my family.
Who would have though it? All my imaginary friends, that's who.
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Hilariously enough, there's a history of this in my family.
Who would have though it? All my imaginary friends, that's who.
@Doctor-Phibes said in Schizophrenia Genes Identified:
Hilariously enough, there's a history of this in my family.
Who would have though it? All my imaginary friends, that's who.
Well, that's just cray-cray.
