Skip to content
  • Categories
  • Recent
  • Tags
  • Popular
  • Users
  • Groups
Skins
  • Light
  • Cerulean
  • Cosmo
  • Flatly
  • Journal
  • Litera
  • Lumen
  • Lux
  • Materia
  • Minty
  • Morph
  • Pulse
  • Sandstone
  • Simplex
  • Sketchy
  • Spacelab
  • United
  • Yeti
  • Zephyr
  • Dark
  • Cyborg
  • Darkly
  • Quartz
  • Slate
  • Solar
  • Superhero
  • Vapor

  • Default (No Skin)
  • No Skin
Collapse

The New Coffee Room

  1. TNCR
  2. General Discussion
  3. Antibody Titers Before and After

Antibody Titers Before and After

Scheduled Pinned Locked Moved General Discussion
1 Posts 1 Posters 21 Views
  • Oldest to Newest
  • Newest to Oldest
  • Most Votes
Reply
  • Reply as topic
Log in to reply
This topic has been deleted. Only users with topic management privileges can see it.
  • George KG Offline
    George KG Offline
    George K
    wrote on last edited by
    #1

    https://jamanetwork.com/journals/jama/fullarticle/2786096?guestAccessKey=8168799b-fe68-4f50-90a8-e8348fe03217&utm_source=silverchair&utm_campaign=jama_network&utm_content=covid_weekly_highlights&utm_medium=email

    Results

    Among the 97 study participants, the median age was 70 years (IQR, 67-74), and 61% were women (Table 1). Before the third dose (median, 221 days [IQR, 218-225] after the first vaccination), 94 participants (97%) were seropositive. The median titer level increased significantly after the third dose, from a median of 440 AU/mL (IQR, 294-923) to 25 468 AU/mL (IQR, 14 203-36 618) (P < .001), and all participants became seropositive (Table 1). No significant correlation was observed between age and IgG titers (R = −0.075; P = .47). No variable was significantly associated with higher IgG titers, including age, sex, days after first vaccination, and comorbidities (Table 2). No major adverse events were reported.

    Discussion

    This study found that a third BNT162b2 dose in adults aged 60 years and older was associated with significantly increased IgG titers after 10 to 19 days, with no major adverse events.

    A third dose of the SARS-CoV-2 mRNA-1273 vaccine (Moderna) induced seropositivity in 49% of kidney transplant recipients who did not respond after 2 vaccine doses,3 although this observation cannot be generalized to older adults. In a study from Israel among 1 137 804 adults aged 60 years and older who had received 2 BNT162b2 doses 5 or more months earlier, a third dose was associated with lower rates of confirmed SARS-CoV-2 infections and severe illness.4 This study adds serologic data to the clinical data on response to a third dose in adults aged 60 years or older.

    Study limitations include the small sample size, short follow-up, and lack of cellular immunity testing and neutralizing antibody testing. Although accumulating evidence suggests that IgG response is a correlate of disease protection,5 cellular immunity has also been suggested to play an important role in protecting against SARS-CoV-2.6

    "Now look here, you Baltic gas passer... " - Mik, 6/14/08

    The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

    1 Reply Last reply
    Reply
    • Reply as topic
    Log in to reply
    • Oldest to Newest
    • Newest to Oldest
    • Most Votes


    • Login

    • Don't have an account? Register

    • Login or register to search.
    • First post
      Last post
    0
    • Categories
    • Recent
    • Tags
    • Popular
    • Users
    • Groups