Ivermectin. Again.
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@Doctor-Phibes said in Ivermectin. Again.:
On the positive side, Group B was completely free of worms
You kid - but I hear that could be why some of the trials in areas with parasites can show benefits to using ivermectin for Covid.
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
Just a hypothesis though.
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@Doctor-Phibes said in Ivermectin. Again.:
On the positive side, Group B was completely free of worms
You kid - but I hear that could be why some of the trials in areas with parasites can show benefits to using ivermectin for Covid.
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
Just a hypothesis though.
@xenon said in Ivermectin. Again.:
@Doctor-Phibes said in Ivermectin. Again.:
On the positive side, Group B was completely free of worms
You kid - but I hear that could be why some of the trials in areas with parasites can show benefits to using ivermectin for Covid.
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
Just a hypothesis though.
Might be a pretty good one.
In my career, I've only seen one patient with seven intestinal parasites. She was direct from rural Vietnam.
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@Doctor-Phibes said in Ivermectin. Again.:
On the positive side, Group B was completely free of worms
You kid - but I hear that could be why some of the trials in areas with parasites can show benefits to using ivermectin for Covid.
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
Just a hypothesis though.
@xenon said in Ivermectin. Again.:
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
I doubt that a significant cohort of the COVID population is concurrently infected with any kind of worm. But, your point might be valid.
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
What happens in vivo is a whole 'nother thing.
"Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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@xenon said in Ivermectin. Again.:
Basically - fighting off parasites + covid at the same time is harder than fighting off covid.
I doubt that a significant cohort of the COVID population is concurrently infected with any kind of worm. But, your point might be valid.
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
What happens in vivo is a whole 'nother thing.
@George-K said in Ivermectin. Again.:
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
The infamous bleach would probably work that way, too
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@George-K said in Ivermectin. Again.:
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
The infamous bleach would probably work that way, too
@Doctor-Phibes said in Ivermectin. Again.:
@George-K said in Ivermectin. Again.:
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
The infamous bleach would probably work that way, too
There actually was research years ago about dilute hypochlorite solutions as a virocide.
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@Doctor-Phibes said in Ivermectin. Again.:
@George-K said in Ivermectin. Again.:
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
The infamous bleach would probably work that way, too
There actually was research years ago about dilute hypochlorite solutions as a virocide.
@Jolly said in Ivermectin. Again.:
@Doctor-Phibes said in Ivermectin. Again.:
@George-K said in Ivermectin. Again.:
What I noticed, early on in all of these debates about other drugs, is that, for the most part, were in vitro - showing that a Petri dish infused with a virus and the drug showed inhibition of the virus.
The infamous bleach would probably work that way, too
There actually was research years ago about dilute hypochlorite solutions as a virocide.
Some thru hikers use diluted bleach to sanitize their water, the idea being that they wouldn't be doing it long enough for permanent kidney damage.
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https://www.washingtonpost.com/nation/2022/02/25/new-hampshire-hospital-threats-qanon/
... Calls were flooding into the [hospital's] switchboard, and senior staff members were receiving a flurry of voice messages and emails to their work accounts. The callers were impassioned and vehement, demanding that the hospital begin treating a covid patient in its care with ivermectin, an anti-parasitic drug. As the day went on, the volume of calls grew so large that the hospital shut down its main number.
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That morning was only the beginning. The calls and emails — mobilized by a group calling itself the Truth Seekers 88 — continued for more than a week. The hospital limited access to one entrance, and local police posted a cruiser there 24 hours a day. Several of the communications were threatening, Caple said, including a voice mail in which a caller warned of a “military extraction” of the patient from the hospital. Nine days after the calls and emails began, she said, the hospital received a bomb threat for the first time in its history.
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https://www.nejm.org/doi/full/10.1056/NEJMoa2115869#.YkUKwiDgnz8.twitter
BACKGROUND
The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.METHODS
We conducted a double-blind, randomized, placebo-controlled, adaptive platform trial involving symptomatic SARS-CoV-2–positive adults recruited from 12 public health clinics in Brazil. Patients who had had symptoms of Covid-19 for up to 7 days and had at least one risk factor for disease progression were randomly assigned to receive ivermectin (400 μg per kilogram of body weight) once daily for 3 days or placebo. (The trial also involved other interventions that are not reported here.) The primary composite outcome was hospitalization due to Covid-19 within 28 days after randomization or an emergency department visit due to clinical worsening of Covid-19 (defined as the participant remaining under observation for >6 hours) within 28 days after randomization.RESULTS
A total of 3515 patients were randomly assigned to receive ivermectin (679 patients), placebo (679), or another intervention (2157). Overall, 100 patients (14.7%) in the ivermectin group had a primary-outcome event, as compared with 111 (16.3%) in the placebo group (relative risk, 0.90; 95% Bayesian credible interval, 0.70 to 1.16). Of the 211 primary-outcome events, 171 (81.0%) were hospital admissions. Findings were similar to the primary analysis in a modified intention-to-treat analysis that included only patients who received at least one dose of ivermectin or placebo (relative risk, 0.89; 95% Bayesian credible interval, 0.69 to 1.15) and in a per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen (relative risk, 0.94; 95% Bayesian credible interval, 0.67 to 1.35). There were no significant effects of ivermectin use on secondary outcomes or adverse events.CONCLUSIONS
Treatment with ivermectin did not result in a lower incidence of medical admission to a hospital due to progression of Covid-19 or of prolonged emergency department observation among outpatients with an early diagnosis of Covid-19."Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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I saw an amazing meta analysis on Ivermectin studies and it makes a strong case that it helps in parts of the world precisely because it kills worms.
The worm infections make it harder to fight Covid. Also corticosteroid based Covid treatments cause the worms to multiple dramatically. That’s why the tests with the strongest results for ivermectin come from places that are teeming with worms, eg Bangladesh, East India, Colombia, etc whereas studies in the developed world show no significant effect.
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https://www.nejm.org/doi/full/10.1056/NEJMoa2115869#.YkUKwiDgnz8.twitter
BACKGROUND
The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.METHODS
We conducted a double-blind, randomized, placebo-controlled, adaptive platform trial involving symptomatic SARS-CoV-2–positive adults recruited from 12 public health clinics in Brazil. Patients who had had symptoms of Covid-19 for up to 7 days and had at least one risk factor for disease progression were randomly assigned to receive ivermectin (400 μg per kilogram of body weight) once daily for 3 days or placebo. (The trial also involved other interventions that are not reported here.) The primary composite outcome was hospitalization due to Covid-19 within 28 days after randomization or an emergency department visit due to clinical worsening of Covid-19 (defined as the participant remaining under observation for >6 hours) within 28 days after randomization.RESULTS
A total of 3515 patients were randomly assigned to receive ivermectin (679 patients), placebo (679), or another intervention (2157). Overall, 100 patients (14.7%) in the ivermectin group had a primary-outcome event, as compared with 111 (16.3%) in the placebo group (relative risk, 0.90; 95% Bayesian credible interval, 0.70 to 1.16). Of the 211 primary-outcome events, 171 (81.0%) were hospital admissions. Findings were similar to the primary analysis in a modified intention-to-treat analysis that included only patients who received at least one dose of ivermectin or placebo (relative risk, 0.89; 95% Bayesian credible interval, 0.69 to 1.15) and in a per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen (relative risk, 0.94; 95% Bayesian credible interval, 0.67 to 1.35). There were no significant effects of ivermectin use on secondary outcomes or adverse events.CONCLUSIONS
Treatment with ivermectin did not result in a lower incidence of medical admission to a hospital due to progression of Covid-19 or of prolonged emergency department observation among outpatients with an early diagnosis of Covid-19.@George-K said in Ivermectin. Again.:
https://www.nejm.org/doi/full/10.1056/NEJMoa2115869#.YkUKwiDgnz8.twitter
BACKGROUND
The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.METHODS
We conducted a double-blind, randomized, placebo-controlled, adaptive platform trial involving symptomatic SARS-CoV-2–positive adults recruited from 12 public health clinics in Brazil. Patients who had had symptoms of Covid-19 for up to 7 days and had at least one risk factor for disease progression were randomly assigned to receive ivermectin (400 μg per kilogram of body weight) once daily for 3 days or placebo. (The trial also involved other interventions that are not reported here.) The primary composite outcome was hospitalization due to Covid-19 within 28 days after randomization or an emergency department visit due to clinical worsening of Covid-19 (defined as the participant remaining under observation for >6 hours) within 28 days after randomization.RESULTS
A total of 3515 patients were randomly assigned to receive ivermectin (679 patients), placebo (679), or another intervention (2157). Overall, 100 patients (14.7%) in the ivermectin group had a primary-outcome event, as compared with 111 (16.3%) in the placebo group (relative risk, 0.90; 95% Bayesian credible interval, 0.70 to 1.16). Of the 211 primary-outcome events, 171 (81.0%) were hospital admissions. Findings were similar to the primary analysis in a modified intention-to-treat analysis that included only patients who received at least one dose of ivermectin or placebo (relative risk, 0.89; 95% Bayesian credible interval, 0.69 to 1.15) and in a per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen (relative risk, 0.94; 95% Bayesian credible interval, 0.67 to 1.35). There were no significant effects of ivermectin use on secondary outcomes or adverse events.CONCLUSIONS
Treatment with ivermectin did not result in a lower incidence of medical admission to a hospital due to progression of Covid-19 or of prolonged emergency department observation among outpatients with an early diagnosis of Covid-19.Don't doubt it. Proponents of Ivermectin have never claimed it worked well in acute cases. They've advocated taking it prophylactically or at the first onset of symptoms. I'd like to see a good study of where that was done.
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“Cry havoc and let slip the DOGE of war!”
Those who cheered as J-6 American prisoners were locked in solitary for 18 months without trial, now suddenly fight tooth and nail for foreign terrorists’ "due process". — Buck Sexton
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@Jolly That seems kind of weird to me. If I want to fix lights in my house, I would call a electrician.
If I want good information on medicines, i would rely on medical people on politicians.
Not sure what I would rely on politicians for? LOL
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I wonder if they know that Ivermectin can be used to induce abortions.
(I just made that up, but it would be bloody hilarious if it was true)
I was only joking
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Key Points
Question Does adding ivermectin, an inexpensive and widely available antiparasitic drug, to the standard of care reduce the risk of severe disease in patients with COVID-19 and comorbidities?Findings In this open-label randomized clinical trial of high-risk patients with COVID-19 in Malaysia, a 5-day course of oral ivermectin administered during the first week of illness did not reduce the risk of developing severe disease compared with standard of care alone.
Meaning The study findings do not support the use of ivermectin for patients with COVID-19.
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Question: Does ivermectin, 400 μg/kg, daily for 3 days, compared with placebo, shorten symptom duration among adult (≥30 years) outpatients in the US with symptomatic mild to moderate COVID-19?
Findings: In this double-blinded, randomized, placebo-controlled platform trial conducted in the US during a period of Delta and Omicron variant predominance, and that included 1591 adult outpatients with COVID-19, the posterior probability of improvement in time to recovery in those treated with ivermectin vs placebo had a hazard ratio of 1.07, with a posterior probability of benefit of .91. This did not meet the prespecified threshold of posterior probability greater than .95.
Meaning: These findings do not support the use of ivermectin in outpatients with mild to moderate COVID-19.
