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Probably coming to a close.
The last time Brady was an underdog in a regular season game came on Nov. 30, 2014, when the Patriots closed as a 3-point underdog to the Green Bay Packers in a game that New England lost 26-21.
https://www.cbssports.com/nfl/news/tom-brady-has-an-improbable-six-year-streak-thats-likely-going-to-end-against-the-saints-in-week-1/
The Saints never play well in their opener.