Lucky me
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i usually don't get ahead of the latest longevity trends, but I've been rocking this trio for several years.
A recent clinical trial with over 700 older adults showed that omega-3 supplementation may have geroprotective benefits and slow biological aging.
The study, conducted over three years, also suggested that combining omega-3 supplementation with vitamin D and exercise could provide additive benefits.
Participants aged 70 and older were divided into eight groups receiving different treatments, including vitamin D, omega-3, and a home exercise program.
The researchers found that omega-3 consumption moderately slowed biological aging, and combining omega-3, vitamin D, and exercise worked even better.
Additionally, the three interventions together had the biggest impact on lowering cancer risk and preventing frailty over three years. The researchers suggest that each intervention works through different but related mechanisms, and when combined, they reinforce each other, creating a stronger overall effect.
RESEARCH PAPER
Heike A. Bischoff-Ferrari et al., “Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial”, Nature Aging (2025) -
https://www.nature.com/articles/s43587-024-00793-y
I'm good, except I only take 1000 IU of D. 7 hours of intense to moderate exercise per week.
The DO-HEALTH Bio-Age trial included 777 of the 2,157 DO-HEALTH participants with DNAm measures at baseline and 3 years. DO-HEALTH was a multicenter randomized controlled trial designed to support healthy longevity. It enrolled 2,157 generally healthy and active adults aged 70 years and older across five countries in Europe22,26. DO-HEALTH was designed as a 2 × 2 × 2 factorial study testing the effects of vitamin D (2,000 IU per day), omega-3 (1 g per day) and SHEP (three times 30 min per week) individually and in combination over an intervention period of 3 years. Participants were randomized to one of eight treatment arms, and all were followed up with yearly examinations and in-person telephone calls every 3 months. Blood was collected at baseline and 1, 2 and 3 years of follow-up, and DNA was extracted and biobanked.
