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The New Coffee Room

  1. TNCR
  2. General Discussion
  3. David Sinclair - "Longevity Guy"

David Sinclair - "Longevity Guy"

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  • kluursK Offline
    kluursK Offline
    kluurs
    wrote on last edited by
    #4

    I've been following this guy for a while. He's done a lot of repudiation of food fads and other of the various crazes.

    image.png

    1 Reply Last reply
    • George KG Offline
      George KG Offline
      George K
      wrote on last edited by
      #5

      Yup to both of you. The book was a fascinating read - especially the basic science stuff. Never thought I'd find yeast interesting.

      But.. he has his own brand of supplements, which makes you think...

      alt text

      "Now look here, you Baltic gas passer... " - Mik, 6/14/08

      The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

      1 Reply Last reply
      • jon-nycJ Online
        jon-nycJ Online
        jon-nyc
        wrote on last edited by
        #6

        He does? In the book he talks about not revealing what brand he uses.

        They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

        George KG 1 Reply Last reply
        • jon-nycJ Online
          jon-nycJ Online
          jon-nyc
          wrote on last edited by
          #7

          https://www.nad.com/news/david-sinclairs-2024-anti-aging-supplement-protocol

          They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

          1 Reply Last reply
          • jon-nycJ jon-nyc

            He does? In the book he talks about not revealing what brand he uses.

            George KG Offline
            George KG Offline
            George K
            wrote on last edited by
            #8

            @jon-nyc said in David Sinclair - "Longevity Guy":

            He does? In the book he talks about not revealing what brand he uses.

            Somewhere, I remember reading that he is a major owner of a supplement manufacturer.

            "Now look here, you Baltic gas passer... " - Mik, 6/14/08

            The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

            jon-nycJ 1 Reply Last reply
            • RenaudaR Offline
              RenaudaR Offline
              Renauda
              wrote on last edited by Renauda
              #9

              Okay so let’s cut to the chase.

              How does Fauci fit into Sinclair’s snake oil scam? Or better, how does Sinclair’s fountain of youth scam factor into Fauci’s gain of function conspiracy and cover up with the Wuhan Institute and the release of the Gimp Covid?

              Elbows up!

              1 Reply Last reply
              • George KG George K

                @jon-nyc said in David Sinclair - "Longevity Guy":

                He does? In the book he talks about not revealing what brand he uses.

                Somewhere, I remember reading that he is a major owner of a supplement manufacturer.

                jon-nycJ Online
                jon-nycJ Online
                jon-nyc
                wrote on last edited by
                #10

                @George-K said in David Sinclair - "Longevity Guy":

                @jon-nyc said in David Sinclair - "Longevity Guy":

                He does? In the book he talks about not revealing what brand he uses.

                Somewhere, I remember reading that he is a major owner of a supplement manufacturer.

                I find it hard to believe. Could you be confusing him for someone else? In his book he goes on and on about not even revealing brands he uses despite being asked constantly. I understand why he’s asked because there are a million supplements out there many slightly different in ways a non-expert wouldn’t understand and who knows how reputable.

                They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

                George KG 1 Reply Last reply
                • jon-nycJ jon-nyc

                  @George-K said in David Sinclair - "Longevity Guy":

                  @jon-nyc said in David Sinclair - "Longevity Guy":

                  He does? In the book he talks about not revealing what brand he uses.

                  Somewhere, I remember reading that he is a major owner of a supplement manufacturer.

                  I find it hard to believe. Could you be confusing him for someone else? In his book he goes on and on about not even revealing brands he uses despite being asked constantly. I understand why he’s asked because there are a million supplements out there many slightly different in ways a non-expert wouldn’t understand and who knows how reputable.

                  George KG Offline
                  George KG Offline
                  George K
                  wrote on last edited by
                  #11

                  @jon-nyc said in David Sinclair - "Longevity Guy":

                  In his book he goes on and on about not even revealing brands he uses despite being asked constantly

                  I remember reading that as well.

                  Perhaps this is what I saw.

                  https://www.huffpost.com/entry/david-sinclair-aging-harvard-resveratrol_b_5c61ee61e4b038faea137fb9

                  His financial interests include being listed as an inventor on a patent licensed to Elysium Health, a supplement company that sells a NAD booster in pills for $60 a bottle....

                  Elysium, co-founded in 2014 by a prominent MIT scientist to commercialize the molecule nicotinamide riboside, a type of NAD booster, highlights its “exclusive” licensing agreement with Harvard and the Mayo Clinic and Sinclair’s role as an inventor. According to the company’s press release, the agreement is aimed at supplements that slow “aging and age-related diseases.”

                  I wonder if he gets royalties from his patent.

                  https://longevity.technology/news/consumer-longevity-company-tally-launches-new-daily-supplement/

                  Longevity.Technology: The company, which was co-founded by longevity heavyweight David Sinclair, is banking on synergy with its latest release; the new supplement combines three ingredients that work in concert to target established hallmarks of aging and optimize performance at the cellular level. In addition, Amplify complements Tally Health’s existing daily foundational longevity supplement, Vitality.

                  The molecules in Amplify are designed to work together to slow aging by improving cellular energy production, activating the metabolic sensor AMP-activated protein kinase (AMPK) and inducing autophagy. The supplement’s active elements collectively mimic the benefits of clearing out the pro-aging amino acid methionine, boosting energy production and exercise performance, and improving metabolism. Amplify optimizes cellular performance through these processes by ridding the body of damaged or dysfunctional material and promoting heightened functio

                  "Now look here, you Baltic gas passer... " - Mik, 6/14/08

                  The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

                  1 Reply Last reply
                  • jon-nycJ Online
                    jon-nycJ Online
                    jon-nyc
                    wrote on last edited by jon-nyc
                    #12

                    Hmmmm....

                    I read his book and that of Peter Attia and found them both interesting. Given my transplant and the attendant mortality risks, I don't think the 'lifespan' advice is so relevant to me. However the 'healthspan' advice very much is relevant to me and I try to take it into consideration in my daily routines. I find Attia's book much more relevant for me personally, though I think he's somewhat over the top in pretty much everything he does - whether it's swimming, biking, running, or "healthspanning". THere's still a lot to learn from him.

                    I noticed that, the one time Sinclair mentions Attia in his book, he calls him a 'pundit' rather than doctor. Probably a backstory to that.

                    They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

                    1 Reply Last reply
                    • George KG Offline
                      George KG Offline
                      George K
                      wrote on last edited by
                      #13

                      Yep. There seems to be no love lost between the two, though it looks like Attia is much more outspoken about Sinclair than vice-versa.

                      But...as I said, I loved Lifespan. Just fascinating stuff. I'm sure that doing it on audio made a lot of stuff get lost, but the gist was there.

                      "Now look here, you Baltic gas passer... " - Mik, 6/14/08

                      The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

                      jon-nycJ 1 Reply Last reply
                      • George KG Offline
                        George KG Offline
                        George K
                        wrote on last edited by
                        #14

                        Also, being the doddering old fool that I am, I don't recall Attia's book...

                        Gonna have to seek it out.

                        "Now look here, you Baltic gas passer... " - Mik, 6/14/08

                        The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.

                        1 Reply Last reply
                        • George KG George K

                          Star Scientist’s Claim of ‘Reverse Aging’ Draws Hail of Criticism

                          The 54-year-old has built his brand on the idea that aging is a treatable disease. The notion has proven so seductive that legions of acolytes follow his online postings about his research and the cocktails of supplements he consumes to stave off the inevitable.

                          His social-media accounts are a platform for assertions that his work is pushing nearer to a fountain of youth. He claimed last year that a gene therapy invented in his Harvard lab and being developed by a company he co-founded, Life Biosciences, had reversed aging and restored vision in monkeys. “Next up: age reversal in humans,” he wrote on X and Instagram.

                          On Feb. 29, in the eyes of many other scientists working to unlock the mysteries of aging, he went too far.

                          Another company he co-founded, Animal Biosciences, quoted him in a press release saying that a supplement it had developed had reversed aging in dogs. Scientists who study aging can’t even agree on what it means to “reverse” aging, much less how to measure it.

                          The response was swift and harsh. The Academy for Health and Lifespan Research, a group of about 60 scientists that Sinclair co-founded and led, was hit with a cascade of resignations by members outraged by his claims. One scientist who quit referred to Sinclair on X as a “snake oil salesman.”

                          Days later, in a tense video meeting, the academy’s five other board members pressed Sinclair to resign as president. He contended that the press release contained an inaccurate quote, according to people who were in the meeting, but he later stepped down.

                          Sinclair’s work is published regularly in top-tier scientific journals and has brought attention to an emerging field vying for credibility and funding. He has parlayed his research into hundreds of millions of dollars of investment in various companies, more than 50 patents and prominence as a longevity influencer.

                          Along the way, his claims—especially in his social-media posts, interviews and his book—have drawn criticism from scientists who have accused him of hyping his research and extolling unproven products, including some from companies in which he had a financial interest.

                          “My lab’s ideas and findings are typically ahead of the curve, which is why some peers might feel the research is overstated at the time,” Sinclair said to The Wall Street Journal in an email. “I stand behind my track record as a trusted scientist in one of the most competitive professions of all.” He said he doesn’t engage with social-media critics, including those calling him a snake oil salesman, and that many such comments are “nothing more than mischaracterizations.”

                          Dr. Nir Barzilai, the new president of the Academy for Health and Lifespan Research and the director of the Institute for Aging Research at Albert Einstein College of Medicine, said Sinclair’s comment about the dog research and his commercial interest in Animal Biosciences crossed a line. “The data is not good, you’re calling it the wrong thing, and then you’re selling it,” he said. “The selling is a step too far.”

                          jon-nycJ Online
                          jon-nycJ Online
                          jon-nyc
                          wrote on last edited by
                          #15

                          Scientists who study aging can’t even agree on what it means to “reverse” aging, much less how to measure it.

                          A charitable read would be that some particular deleterious cellular process that occurs with aging was reversed, which seems really plausible.

                          That's not to say that it couldn't be exaggerated in a press release.

                          They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

                          1 Reply Last reply
                          • George KG George K

                            Yep. There seems to be no love lost between the two, though it looks like Attia is much more outspoken about Sinclair than vice-versa.

                            But...as I said, I loved Lifespan. Just fascinating stuff. I'm sure that doing it on audio made a lot of stuff get lost, but the gist was there.

                            jon-nycJ Online
                            jon-nycJ Online
                            jon-nyc
                            wrote on last edited by jon-nyc
                            #16

                            @George-K said in David Sinclair - "Longevity Guy":

                            Yep. There seems to be no love lost between the two, though it looks like Attia is much more outspoken about Sinclair than vice-versa.

                            But...as I said, I loved Lifespan. Just fascinating stuff. I'm sure that doing it on audio made a lot of stuff get lost, but the gist was there.

                            I did them both on audio, listening to them mostly while working out or biking. Very motivating.

                            Also, it's cool that both authors narrate their own works.

                            They’ll end up, after a lot of drama, with the same formula they use every time they have a trifecta: take away health care and food assistance from low income families and use the money to fund tax cuts for their donors.

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