Antibody Titers after 3rd Moderna Dose
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https://jamanetwork.com/journals/jama/fullarticle/2786096
Results:
Among the 97 study participants, the median age was 70 years (IQR, 67-74), and 61% were women (Table 1). Before the third dose (median, 221 days [IQR, 218-225] after the first vaccination), 94 participants (97%) were seropositive. The median titer level increased significantly after the third dose, from a median of 440 AU/mL (IQR, 294-923) to 25 468 AU/mL (IQR, 14 203-36 618) (P < .001), and all participants became seropositive (Table 1). No significant correlation was observed between age and IgG titers (R = −0.075; P = .47). No variable was significantly associated with higher IgG titers, including age, sex, days after first vaccination, and comorbidities (Table 2). No major adverse events were reported.
Discussion:
This study found that a third BNT162b2 dose in adults aged 60 years and older was associated with significantly increased IgG titers after 10 to 19 days, with no major adverse events.
A third dose of the SARS-CoV-2 mRNA-1273 vaccine (Moderna) induced seropositivity in 49% of kidney transplant recipients who did not respond after 2 vaccine doses,3 although this observation cannot be generalized to older adults. In a study from Israel among 1 137 804 adults aged 60 years and older who had received 2 BNT162b2 doses 5 or more months earlier, a third dose was associated with lower rates of confirmed SARS-CoV-2 infections and severe illness.4 This study adds serologic data to the clinical data on response to a third dose in adults aged 60 years or older.
Study limitations include the small sample size, short follow-up, and lack of cellular immunity testing and neutralizing antibody testing. Although accumulating evidence suggests that IgG response is a correlate of disease protection,5 cellular immunity has also been suggested to play an important role in protecting against SARS-CoV-2.6
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https://jamanetwork.com/journals/jama/fullarticle/2786096
Results:
Among the 97 study participants, the median age was 70 years (IQR, 67-74), and 61% were women (Table 1). Before the third dose (median, 221 days [IQR, 218-225] after the first vaccination), 94 participants (97%) were seropositive. The median titer level increased significantly after the third dose, from a median of 440 AU/mL (IQR, 294-923) to 25 468 AU/mL (IQR, 14 203-36 618) (P < .001), and all participants became seropositive (Table 1). No significant correlation was observed between age and IgG titers (R = −0.075; P = .47). No variable was significantly associated with higher IgG titers, including age, sex, days after first vaccination, and comorbidities (Table 2). No major adverse events were reported.
Discussion:
This study found that a third BNT162b2 dose in adults aged 60 years and older was associated with significantly increased IgG titers after 10 to 19 days, with no major adverse events.
A third dose of the SARS-CoV-2 mRNA-1273 vaccine (Moderna) induced seropositivity in 49% of kidney transplant recipients who did not respond after 2 vaccine doses,3 although this observation cannot be generalized to older adults. In a study from Israel among 1 137 804 adults aged 60 years and older who had received 2 BNT162b2 doses 5 or more months earlier, a third dose was associated with lower rates of confirmed SARS-CoV-2 infections and severe illness.4 This study adds serologic data to the clinical data on response to a third dose in adults aged 60 years or older.
Study limitations include the small sample size, short follow-up, and lack of cellular immunity testing and neutralizing antibody testing. Although accumulating evidence suggests that IgG response is a correlate of disease protection,5 cellular immunity has also been suggested to play an important role in protecting against SARS-CoV-2.6
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@george-k Simple English please! 555
@taiwan_girl said in Antibody Titers after 3rd Moderna Dose:
@george-k Simple English please! 555
titer [ti´ter]
the quantity of a substance required to react with or to correspond to a given amount of another substance.
agglutination titer the highest dilution of a serum which causes clumping of microorganisms or other particulate antigens.seropositive [se″ro-poz´ĭ-tiv]
showing positive results on serologic examination; showing a high level of antibody. -
@george-k Simple English please! 555
@taiwan_girl said in Antibody Titers after 3rd Moderna Dose:
Simple English
3rd Moderna shot is good
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@taiwan_girl said in Antibody Titers after 3rd Moderna Dose:
Simple English
3rd Moderna shot is good
@copper Thanks!!!
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