Ivermectin
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@mik this is the same thinking as HCQ. The fact that a drug may work in vitro, in a cell culture does not translate to you can expect it to work in vivo.
And, a somewhat related point, Plaquenil (HCQ) was first developed as an anti-malarial, but discovered to have anti-arthritic properties, effectiveness in SLE, and porphyria as well. The fact that ivermectin is an anti parasitic drug does not, per se, preclude its usefulness in other situations.
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@mik said in Ivermectin:
Can we just stop with the personal attacks?
Probably not, if I'm confronted with mindless attacks that anybody who so much as entertains notions I entertain are incomprehensibly divorced from reality.
Meanwhile, back on topic - is there any understanding (I haven't read all the available literature) of how or why ivermectin works or might work against COVID? I haven't seen it.
There is at least some small signal in the evidence that suggests Ivermectin has some effect, especially as a preventative against COVID. Even the sceptics acknowledge that. They also acknowledge that Ivermectin hasn't been studied enough to know one way or another. If it is effective, I don't think anybody has a clue as to the mechanism.
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I'm down with more studies. Actually a shitload more studies. Treatment's definitely a missing piece. Obviously strong enough control on an infection would be just as good if not better than a vaccine.
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@mik said in Ivermectin:
Yep. Study away. Then talk to me about it as a treatment.
+3
With hydroxychoroquine it was the only hope at the time and I was frustrated that it was so roundly criticized as it felt political and there was no other hope.
With ivermectin it would be a dream come true for billions of people that really can’t get the vaccine.
My sensitivity arises when I perceive it as proposed as the better “or” rather than “and”.
Some of the proponents are on record in their discussion of Ivermectin as the better approach and there is a scientific obligation to correct that- until proven otherwise.
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Major study of Ivermectin finds 'no effect whatsoever'
Ivermectin, the latest supposed treatment for COVID-19 being touted by anti-vaccination groups, had "no effect whatsoever" on the disease, according to a large patient study.
That's the conclusion of the Together Trial, which has subjected several purported nonvaccine treatments for COVID-19 to carefully designed clinical testing. The trial is supervised by McMaster University in Hamilton, Canada, and conducted in Brazil.
One of the trial's principal investigators, Edward Mills of McMaster, presented the results from the Ivermectin arms of the study at an Aug. 6 symposium sponsored by the National Institutes of Health.
I've had enough abuse and so have the other clinical trialists doing Ivermectin. Others working in this area have been threatened, their families have been threatened, they've been defamed.
Edward Mills, COVID researcherAmong the 1,500 patients in the study, he said, Ivermectin showed "no effect whatsoever" on the trial's outcome goals — whether patients required extended observation in the emergency room or hospitalization.
"In our specific trial," he said, "we do not see the treatment benefit that a lot of the advocates believe should have been" seen.
The study's results on Ivermectin haven't been formally published or peer-reviewed. Earlier peer-reviewed results from the Together Trial related to the antimalarial drug hydroxychloroquine, which had been touted as a miracle treatment for COVID by then-President Trump, were published in April; they showed no significant therapeutic effect on the virus.
The findings on Ivermectin are yet another blow for advocates promoting the drug as a magic bullet against COVID-19. Ivermectin was developed as a treatment for parasitical diseases, mostly for veterinarians, though it's also used against some human parasites.
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Here's why I hate the media.
Personally, I have no opinion on the effectiveness of ivermectin. This is NOT an endorsement of the drug.
CNN's Headline: Health officials warn people not to take a drug meant for livestock to ward off or treat Covid-19
Mississippi health officials are warning residents not to take an anti-parasitic drug -- in most cases, a formulation purchased at livestock supply centers -- to treat or prevent Covid-19.
The Mississippi State Department of Health issued an alert on Friday that the Mississippi Poison Control Center has received an increasing number of calls from people who have taken the drug known as ivermectin -- and that at least 70% of such calls related to "ingestion of livestock or animal formulations of ivermectin purchased at livestock supply centers."
While there are human uses for the drug, the US Food and Drug Administration has not approved ivermectin to treat or prevent Covid-19 in humans and the drug is not an anti-viral medication.
Ah, "while there are human uses...."
So, IOW, it's not just a livestock drug as the headline screams.
Ivermectin, sold under the brand name Stromectol among others, is a medication that is used to treat parasite infestations. In humans, this includes head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis.
Assholes.
"Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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“I am fond of pigs. Dogs look up to us. Cats look down on us. Pigs treat us as equals.” ~Winston S. Churchill
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"Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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@george-k said in Ivermectin:
@mik said in Ivermectin:
I cannot help but wonder what their word choices would have been if t were Trump.
"Stubborn"
"Inflexible"
"Entrenched"Those work?
Maybe “doubled down” or “dug in”.
Look up “Russell conjugation”.
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Apparently, Ivermectin didn't work as well as planned.
Reuters
An anti-vaxx police officer has died in Georgia after a short battle with COVID-19.Captain Joe Manning posted anti-vaxx messages on Facebook and took the drug ivermectin.
A Georgia police officer who frequently posted anti-vaxx messages on Facebook and took an anti-parasitic drug instead of a vaccine has died of COVID-19.
Captain Joe Manning, 57, of the Wayne County Sheriff's Office died on Wednesday after a short battle with the virus, according to local news station WSAV.
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Education is extremely important.
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@horace said in Ivermectin:
A mea culpa was presented about some pro-Ivermectin study that now seems likely to be fraudulent.
I think you're referring to the Egyptian study. I may have linked to it.
A couple of people found that that study was rife with statistical errors, made-up data, and plagiarism.
"Now look here, you Baltic gas passer... " - Mik, 6/14/08
The saying, "Lite is just one damn thing after another," is a gross understatement. The damn things overlap.
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@george-k said in Ivermectin:
@horace said in Ivermectin:
A mea culpa was presented about some pro-Ivermectin study that now seems likely to be fraudulent.
I think you're referring to the Egyptian study. I may have linked to it.
A couple of people found that that study was rife with statistical errors, made-up data, and plagiarism.
Sadly no, I'm not referring to that study. This was another one, I think out of Argentina, which focused on the prophylactic effects of the drug, rather than curative effects. When Bret discussed the Egypt study a couple weeks ago, he shrugged it off, and reminded everybody that he's most excited about the prophylactic value of Ivermectin. Now when discussing this Argentina study, he mentioned that it didn't say anything about the curative properties. Sigh.
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@george-k said in Ivermectin:
Here's why I hate the media.
Personally, I have no opinion on the effectiveness of ivermectin. This is NOT an endorsement of the drug.
CNN's Headline: Health officials warn people not to take a drug meant for livestock to ward off or treat Covid-19
Mississippi health officials are warning residents not to take an anti-parasitic drug -- in most cases, a formulation purchased at livestock supply centers -- to treat or prevent Covid-19.
The Mississippi State Department of Health issued an alert on Friday that the Mississippi Poison Control Center has received an increasing number of calls from people who have taken the drug known as ivermectin -- and that at least 70% of such calls related to "ingestion of livestock or animal formulations of ivermectin purchased at livestock supply centers."
While there are human uses for the drug, the US Food and Drug Administration has not approved ivermectin to treat or prevent Covid-19 in humans and the drug is not an anti-viral medication.
Ah, "while there are human uses...."
So, IOW, it's not just a livestock drug as the headline screams.
Ivermectin, sold under the brand name Stromectol among others, is a medication that is used to treat parasite infestations. In humans, this includes head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis.
Assholes.
Again, this is supposed to be a hard news piece:
Always remember, Operation Valkyrie was an act of sedition.
Warning: I post things that interest me. Read and comment at your own discretion. -
@jolly said in Ivermectin:
Again, this is supposed to be a hard news piece:
https://www.msn.com/en-us/news/tv/ivermectin-debacle-exposes-hypocrisy-of-anti-vaccine-crowd/vi-AANQRE2CNN's Pamela Brown reports this includes an anti-parasitic medicine for horses and cows.
AND HUMANS, you assholes.
