The anti-aging pill

[kluurs]

I'm using NMN, K2, D3 and B12. I'm doing some lifting in addition to running a bit more - so I'm feeling better - but not sure I can assign that to the supplements.

[Doctor Phibes]

I think I'm the only person I know who doesn't take a single tablet for anything.

Unless you count beer. The wonder-tonic.

I'll probably be dead soon.

[George K]

Here's some more anti-aging advice:

https://futurism.com/neoscope/delay-dna-aging-castrated

An international team led by researchers from the University of Otago in New Zealand were able to show that castration of male sheep delays the aging of DNA, and the same principles could apply to humans as well.
“Both farmers and scientists have known for some time that castrated male sheep live on average much longer than their intact counterparts; however, this is the first time anyone has looked at DNA to see if it also ages slower,” said Victoria Sugrue, a researcher at the University of Otago and lead author of a paper about the research published in the journal eLife, in a statement.
The study is a testament to the development of tools that illuminate the rate at which DNA ages. In fact, thanks to cutting edge research, we are now able to estimate the age of humans and other creatures by looking only at their DNA.

[Horace]

@doctor-phibes said in The anti-aging pill:

I think I'm the only person I know who doesn't take a single tablet for anything.

If not for my acid reflux pills, I could say the same.

[George K]

@doctor-phibes said in The anti-aging pill:

I think I'm the only person I know who doesn't take a single tablet for anything.

I was the same until I got to age 45. My thyroid acted up, and I started supplemental thyroid. Since then, it's been about an additional pill per year, LOL.

[Renauda]

@george-k said in The anti-aging pill:

An international team led by researchers from the University of Otago in New Zealand were able to show that castration of male sheep delays the aging of DNA, and the same principles could apply to humans as well.

Does a prostatectomy count the same?

[George K]

@renauda said in The anti-aging pill:

Does a prostatectomy count the same?

Doubtful. If the plums are still there, they're still at work.

[Doctor Phibes]

@horace said in The anti-aging pill:

@doctor-phibes said in The anti-aging pill:

I think I'm the only person I know who doesn't take a single tablet for anything.

If not for my acid reflux pills, I could say the same.

In our twenties we take acid. In our 50's we take acid-reflux.

(Not that I ever took acid, obviously. I always was a boring old fart in that regard)

[Loki]

Metformin is out Rapamycin is in.

[George K]

@loki said in The anti-aging pill:

Rapamycin

“Rapamycin isn’t a panacea. Longer-lived animals might not fare as well on it as shorter-lived ones do; it’s been shown to be toxic to kidneys at high doses over extended periods of time; and it might suppress the immune system over time. That doesn’t mean TOR inhibition is a dead end, though. It might be safe in small or intermittent doses—that worked in mice to extend lifespan12 and in humans dramatically improved the immune responses of elderly people to a flu vaccine.13”

Excerpt From: David A. Sinclair. “Lifespan.” Apple Books.

“There are hundreds of researchers from the TOR inhibition side of the family working in universities and biotech companies to identify “rapalogs,” which are compounds that act on TOR in ways similar to rapamycin but have greater specificity and less toxicity.”

Excerpt From: David A. Sinclair. “Lifespan.” Apple Books.

“Like rapamycin, metformin mimics aspects of calorie restriction. But instead of inhibiting TOR, it limits the metabolic reactions in mitochondria, slowing down the process by which our cellular powerhouses convert macronutrients into energy.20 The result is the activation of AMPK, an enzyme known for its ability to respond to low energy levels and restore the function of mitochondria. It also activates SIRT1, one of my lab’s favorite proteins. Among other beneficial effects, metformin inhibits cancer cell metabolism, increases mitochondrial activity, and removes misfolded proteins.21”

“A study of more than 41,000 metformin users between the ages of 68 and 81 concluded that metformin reduced the likelihood of dementia, cardiovascular disease, cancer, frailty, and depression, and not by a small amount. In one group of already frail subjects, metformin use over the course of nine years reduced dementia by 4 percent, depression by 16 percent, cardiovascular disease by 19 percent, frailty by 24 percent, and cancer by 4 percent.22 In other studies, the protective power of metformin against cancer has been far greater than that. Though not all cancers are suppressed—prostate, bladder, renal, and esophageal cancer seem recalcitrant—more than twenty-five studies have shown a powerful protective effect, sometimes as great as a 40 percent lower risk, most notably for lung, colorectal, pancreatic, and breast cancer.23”

Excerpt From: David A. Sinclair. “Lifespan.” Apple Books.

[Catseye3]

@renauda said in The anti-aging pill:

An international team led by researchers from the University of Otago in New Zealand were able to show that castration of male sheep delays the aging of DNA, and the same principles could apply to humans as well.

Reminds me of an old joke.

Doctor: "If you quit drinking you'll live longer."

Man: "No, it'll just seem longer."

[Renauda]

@george-k said in The anti-aging pill:

@renauda said in The anti-aging pill:

Does a prostatectomy count the same?

Doubtful. If the plums are still there, they're still at work.

I reckoned as much.

[Renauda]

@catseye3

True enough. Good one.

[Loki]

George

You should check out Dr. Peter Attia if you are into anti aging. Would be curious on your perspective.

[Doctor Phibes]

[Larry]

You're only as old as the one you feel....